Macroevolution of complex retroviruses.
Retroviruses can leave a "fossil record" in their hosts' genomes in the form of endogenous retroviruses. Foamy viruses, complex retroviruses that infect mammals, have been notably absent from this record. We have found an endogenous foamy virus within the genomes of sloths and show th...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1826290786630631424 |
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| author | Katzourakis, A Gifford, R Tristem, M Gilbert, M Pybus, O |
| author_facet | Katzourakis, A Gifford, R Tristem, M Gilbert, M Pybus, O |
| author_sort | Katzourakis, A |
| collection | OXFORD |
| description | Retroviruses can leave a "fossil record" in their hosts' genomes in the form of endogenous retroviruses. Foamy viruses, complex retroviruses that infect mammals, have been notably absent from this record. We have found an endogenous foamy virus within the genomes of sloths and show that foamy viruses were infecting mammals more than 100 million years ago and codiverged with their hosts across an entire geological era. Our analysis highlights the role of evolutionary constraint in maintaining viral genome structure and indicates that accessory genes and mammalian mechanisms of innate immunity are the products of macroevolutionary conflict played out over a geological time scale. |
| first_indexed | 2024-03-07T02:49:31Z |
| format | Journal article |
| id | oxford-uuid:ad309d52-5fbb-4b88-8ac0-2a3ce2167de7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:49:31Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:ad309d52-5fbb-4b88-8ac0-2a3ce2167de72022-03-27T03:33:55ZMacroevolution of complex retroviruses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ad309d52-5fbb-4b88-8ac0-2a3ce2167de7EnglishSymplectic Elements at Oxford2009Katzourakis, AGifford, RTristem, MGilbert, MPybus, ORetroviruses can leave a "fossil record" in their hosts' genomes in the form of endogenous retroviruses. Foamy viruses, complex retroviruses that infect mammals, have been notably absent from this record. We have found an endogenous foamy virus within the genomes of sloths and show that foamy viruses were infecting mammals more than 100 million years ago and codiverged with their hosts across an entire geological era. Our analysis highlights the role of evolutionary constraint in maintaining viral genome structure and indicates that accessory genes and mammalian mechanisms of innate immunity are the products of macroevolutionary conflict played out over a geological time scale. |
| spellingShingle | Katzourakis, A Gifford, R Tristem, M Gilbert, M Pybus, O Macroevolution of complex retroviruses. |
| title | Macroevolution of complex retroviruses. |
| title_full | Macroevolution of complex retroviruses. |
| title_fullStr | Macroevolution of complex retroviruses. |
| title_full_unstemmed | Macroevolution of complex retroviruses. |
| title_short | Macroevolution of complex retroviruses. |
| title_sort | macroevolution of complex retroviruses |
| work_keys_str_mv | AT katzourakisa macroevolutionofcomplexretroviruses AT giffordr macroevolutionofcomplexretroviruses AT tristemm macroevolutionofcomplexretroviruses AT gilbertm macroevolutionofcomplexretroviruses AT pybuso macroevolutionofcomplexretroviruses |