Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection.
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in the face of a high quantity of viral antigen....
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
2002
|
| _version_ | 1826290794034626560 |
|---|---|
| author | Reignat, S Webster, G Brown, D Ogg, G King, A Seneviratne, S Dusheiko, G Williams, R Maini, M Bertoletti, A |
| author_facet | Reignat, S Webster, G Brown, D Ogg, G King, A Seneviratne, S Dusheiko, G Williams, R Maini, M Bertoletti, A |
| author_sort | Reignat, S |
| collection | OXFORD |
| description | Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in the face of a high quantity of viral antigen. Although they do not appear to exert immunological pressure in vivo, these CD8 cells are not classically "tolerant" since they proliferate, lyse, and produce antiviral cytokines in vitro. They are characterized by altered HLA/peptide tetramer reactivity, which is not explained by TCR down-regulation or reduced functional avidity and which can be reversed with repetitive stimulation. CD8 cells with altered tetramer binding appear to have a specificity restricted to envelope antigen and not to other HBV antigens, suggesting that mechanisms of CD8 cell dysfunction are differentially regulated according to the antigenic form and presentation of individual viral antigens. |
| first_indexed | 2024-03-07T02:49:39Z |
| format | Journal article |
| id | oxford-uuid:ad3a459c-3c14-4b89-9545-c6a661b7143d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:49:39Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:ad3a459c-3c14-4b89-9545-c6a661b7143d2022-03-27T03:34:14ZEscaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ad3a459c-3c14-4b89-9545-c6a661b7143dEnglishSymplectic Elements at Oxford2002Reignat, SWebster, GBrown, DOgg, GKing, ASeneviratne, SDusheiko, GWilliams, RMaini, MBertoletti, ADeletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in the face of a high quantity of viral antigen. Although they do not appear to exert immunological pressure in vivo, these CD8 cells are not classically "tolerant" since they proliferate, lyse, and produce antiviral cytokines in vitro. They are characterized by altered HLA/peptide tetramer reactivity, which is not explained by TCR down-regulation or reduced functional avidity and which can be reversed with repetitive stimulation. CD8 cells with altered tetramer binding appear to have a specificity restricted to envelope antigen and not to other HBV antigens, suggesting that mechanisms of CD8 cell dysfunction are differentially regulated according to the antigenic form and presentation of individual viral antigens. |
| spellingShingle | Reignat, S Webster, G Brown, D Ogg, G King, A Seneviratne, S Dusheiko, G Williams, R Maini, M Bertoletti, A Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. |
| title | Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. |
| title_full | Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. |
| title_fullStr | Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. |
| title_full_unstemmed | Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. |
| title_short | Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. |
| title_sort | escaping high viral load exhaustion cd8 cells with altered tetramer binding in chronic hepatitis b virus infection |
| work_keys_str_mv | AT reignats escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection AT websterg escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection AT brownd escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection AT oggg escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection AT kinga escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection AT seneviratnes escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection AT dusheikog escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection AT williamsr escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection AT mainim escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection AT bertolettia escapinghighviralloadexhaustioncd8cellswithalteredtetramerbindinginchronichepatitisbvirusinfection |