RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.

RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.

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The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL fusion proteins have distinct leuke...

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Bibliografiska uppgifter
Huvudupphovsmän: Wilkinson, A, Ballabio, E, Geng, H, North, P, Tapia, M, Kerry, J, Biswas, D, Roeder, R, Allis, C, Melnick, A, de Bruijn, M, Milne, T
Materialtyp: Journal article
Språk:English
Publicerad: 2013

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