Exploring the hidden heritability of inflammatory bowel disease
<p style="text-align:justify;"> In recent years the inflammatory bowel diseases (IBD)—Crohn's disease and ulcerative colitis—have emerged as a model for all complex traits in the successful dissection of the molecular basis of inherited susceptibility by non-parametric linkage...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BMJ Publishing Group
2011
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| Summary: | <p style="text-align:justify;"> In recent years the inflammatory bowel diseases (IBD)—Crohn's disease and ulcerative colitis—have emerged as a model for all complex traits in the successful dissection of the molecular basis of inherited susceptibility by non-parametric linkage analysis<sup>1 2</sup> and genome-wide association studies (GWAS).<sup>3–5</sup> The recent meta-analyses of GWAS carried out by the International Inflammatory Bowel Disease Genetics Consortium have now reported the identification of 99 susceptibility loci involved in the pathogenesis of Crohn's disease and ulcerative colitis<sup>4,5</sup>... </p> |
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