Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation

Avian influenza A viruses (IAVs) pose a public health threat, as they are capable of triggering pandemics by crossing species barriers. Replication of avian IAVs in mammalian cells is hindered by species-specific variation in acidic nuclear phosphoprotein 32 (ANP32) proteins, which are essential for...

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Hlavní autoři: Staller, E, Carrique, L, Swann, O, Fan, H, Keown, J, Sheppard, C, Barclay, W, Grimes, J, Fodor, E
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature 2024