The Goldilocks window of personalized chemotherapy: Getting the immune response just right
The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Due to its lymphodepleting effects, chemotherapy has the potenti...
| Main Authors: | , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
American Association for Cancer Research
2019
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| _version_ | 1826290840570429440 |
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| author | Park, D Robertson-Tessi, M Luddy, K Maini, P Bonsall, M Gatenby, R Anderson, A |
| author_facet | Park, D Robertson-Tessi, M Luddy, K Maini, P Bonsall, M Gatenby, R Anderson, A |
| author_sort | Park, D |
| collection | OXFORD |
| description | The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Due to its lymphodepleting effects, chemotherapy has the potential to break this tolerance. In order to investigate this, we created a mathematical modeling framework of tumor-immune dynamics. Our results suggest that optimal chemotherapy scheduling must balance two opposing objectives: maximizing tumor reduction while preserving patient immune function. Successful treatment requires therapy to operate in a 'Goldilocks Window' where patient immune health is not overly compromised. By keeping therapy 'just right', we show that the synergistic effects of immune activation and chemotherapy can maximize tumor reduction and control. |
| first_indexed | 2024-03-07T02:50:21Z |
| format | Journal article |
| id | oxford-uuid:ad7b16d0-1f8d-4185-a9b8-6ba68985d8be |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:50:21Z |
| publishDate | 2019 |
| publisher | American Association for Cancer Research |
| record_format | dspace |
| spelling | oxford-uuid:ad7b16d0-1f8d-4185-a9b8-6ba68985d8be2022-03-27T03:35:52ZThe Goldilocks window of personalized chemotherapy: Getting the immune response just rightJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ad7b16d0-1f8d-4185-a9b8-6ba68985d8beEnglishSymplectic Elements at OxfordAmerican Association for Cancer Research2019Park, DRobertson-Tessi, MLuddy, KMaini, PBonsall, MGatenby, RAnderson, AThe immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Due to its lymphodepleting effects, chemotherapy has the potential to break this tolerance. In order to investigate this, we created a mathematical modeling framework of tumor-immune dynamics. Our results suggest that optimal chemotherapy scheduling must balance two opposing objectives: maximizing tumor reduction while preserving patient immune function. Successful treatment requires therapy to operate in a 'Goldilocks Window' where patient immune health is not overly compromised. By keeping therapy 'just right', we show that the synergistic effects of immune activation and chemotherapy can maximize tumor reduction and control. |
| spellingShingle | Park, D Robertson-Tessi, M Luddy, K Maini, P Bonsall, M Gatenby, R Anderson, A The Goldilocks window of personalized chemotherapy: Getting the immune response just right |
| title | The Goldilocks window of personalized chemotherapy: Getting the immune response just right |
| title_full | The Goldilocks window of personalized chemotherapy: Getting the immune response just right |
| title_fullStr | The Goldilocks window of personalized chemotherapy: Getting the immune response just right |
| title_full_unstemmed | The Goldilocks window of personalized chemotherapy: Getting the immune response just right |
| title_short | The Goldilocks window of personalized chemotherapy: Getting the immune response just right |
| title_sort | goldilocks window of personalized chemotherapy getting the immune response just right |
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