Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response

Adaptive immune responses protect against infection with dengue virus (DENV), yet cross-reactivity with distinct serotypes can precipitate life-threatening clinical disease. We found that clonotypes expressing the T cell antigen receptor (TCR) β-chain variable region 11 (TRBV11-2) were 'prefere...

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Bibliografiske detaljer
Main Authors:	Culshaw, A, Ladell, K, Gras, S, McLaren, J, Miners, K, Farenc, C, van den Heuvel, H, Gostick, E, Dejnirattisai, W, Wangteeraprasert, A, Duangchinda, T, Chotiyarnwong, P, Limpitikul, W, Vasanawathana, S, Malasit, P, Dong, T, Rossjohn, J, Mongkolsapaya, J, Price, D, Screaton, G
Format:	Journal article
Sprog:	English
Udgivet:	Springer Nature 2017

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