Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors.
A range of terpyridine platinum(II) metallo-intercalators with bioactive steroids attached has been created with the aim of localizing cytotoxic drugs. Complexes where the steroid does not interfere with access to the terpyridine are shown to retain potent cytotoxicity and show certain selectivity t...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1797088472306024448 |
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| author | Sánchez-Cano, C Hannon, M |
| author_facet | Sánchez-Cano, C Hannon, M |
| author_sort | Sánchez-Cano, C |
| collection | OXFORD |
| description | A range of terpyridine platinum(II) metallo-intercalators with bioactive steroids attached has been created with the aim of localizing cytotoxic drugs. Complexes where the steroid does not interfere with access to the terpyridine are shown to retain potent cytotoxicity and show certain selectivity towards their natural receptors. Because the intercalation of the terpyridine moiety between the bases of the DNA is the origin of the biological activity, a dramatic decrease of the activity is observed when the access to the terpyridine unit is hindered by the steroidal unit. |
| first_indexed | 2024-03-07T02:50:35Z |
| format | Journal article |
| id | oxford-uuid:ad8d38d7-c887-438e-98f1-1c42a8616d39 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:50:35Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:ad8d38d7-c887-438e-98f1-1c42a8616d392022-03-27T03:36:21ZCytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ad8d38d7-c887-438e-98f1-1c42a8616d39EnglishSymplectic Elements at Oxford2009Sánchez-Cano, CHannon, MA range of terpyridine platinum(II) metallo-intercalators with bioactive steroids attached has been created with the aim of localizing cytotoxic drugs. Complexes where the steroid does not interfere with access to the terpyridine are shown to retain potent cytotoxicity and show certain selectivity towards their natural receptors. Because the intercalation of the terpyridine moiety between the bases of the DNA is the origin of the biological activity, a dramatic decrease of the activity is observed when the access to the terpyridine unit is hindered by the steroidal unit. |
| spellingShingle | Sánchez-Cano, C Hannon, M Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors. |
| title | Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors. |
| title_full | Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors. |
| title_fullStr | Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors. |
| title_full_unstemmed | Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors. |
| title_short | Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors. |
| title_sort | cytotoxicity cellular localisation and biomolecular interaction of non covalent metallo intercalators with appended sex hormone steroid vectors |
| work_keys_str_mv | AT sanchezcanoc cytotoxicitycellularlocalisationandbiomolecularinteractionofnoncovalentmetallointercalatorswithappendedsexhormonesteroidvectors AT hannonm cytotoxicitycellularlocalisationandbiomolecularinteractionofnoncovalentmetallointercalatorswithappendedsexhormonesteroidvectors |