Reverse immunodynamics: a new method for identifying targets of protective immunity

Reverse immunodynamics: a new method for identifying targets of protective immunity

Despite a dramatic increase in our ability to catalogue variation among pathogen genomes, we have made far fewer advances in using this information to identify targets of protective immunity. Epidemiological models predict that strong immune selection can cause antigenic variants to structure into g...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Spensley, K, Wikramaratna, P, Penman, B, Walker, A, Smith, A, Pybus, O, Jean, L, Gupta, S, Lourenco, J
Fformat:	Journal article
Cyhoeddwyd:	Springer Nature 2019

Eitemau Tebyg

From immune equilibrium to immunodynamics
gan: Xiaoping Chen, et al.
Cyhoeddwyd: (2022-11-01)

Immunodynamics of explanted human tumors for immuno‐oncology
gan: Agathe Dubuisson, et al.
Cyhoeddwyd: (2020-12-01)

Radiation immunodynamics in patients with glioblastoma receiving chemoradiation
gan: Lindsey Sloan, et al.
Cyhoeddwyd: (2024-09-01)

Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension
gan: Christoph Tabeling, et al.
Cyhoeddwyd: (2022-06-01)

Immunostimulatory/Immunodynamic model of mRNA‐1273 to guide pediatric vaccine dose selection
gan: Vijay Ivaturi, et al.
Cyhoeddwyd: (2025-01-01)

A first-in-class, non-invasive, immunodynamic biomarker approach for precision immuno-oncology
gan: Jenny Sprooten, et al.
Cyhoeddwyd: (2022-12-01)

Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice
gan: Pulak R. Nath, et al.
Cyhoeddwyd: (2022-12-01)

Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection.
gan: Wikramaratna, P, et al.
Cyhoeddwyd: (2015)

Contact between bird species of different lifespans can promote the emergence of highly pathogenic avian influenza strains.
gan: Wikramaratna, P, et al.
Cyhoeddwyd: (2014)

Comprehensive analyses of immunodynamics and immunoreactivity in response to treatment in ALK-positive non-small-cell lung cancer
gan: Sung Sook Lee, et al.
Cyhoeddwyd: (2020-10-01)

Mathematical Modeling Finds Disparate Interferon Production Rates Drive Strain-Specific Immunodynamics during Deadly Influenza Infection
gan: Emily E. Ackerman, et al.
Cyhoeddwyd: (2022-04-01)

Protocol to study immunodynamics in the tumor microenvironment using a tyramide signal amplification-based immunofluorescent multiplex panel
gan: Jane Siu-Fan Li, et al.
Cyhoeddwyd: (2024-03-01)

The interplay between environmental factors, vector competence and vaccine immunodynamics as possible explanation of the 2019 yellow fever re-emergence in Nigeria
gan: I.N. Abdullahi, et al.
Cyhoeddwyd: (2021-05-01)

Predicting IFN-γ responses after BCG vaccination in humans from macaques: A proof-of-concept study of Immunostimulation/Immunodynamic modelling methods
gan: Rhodes, S, et al.
Cyhoeddwyd: (2017)

MANTIS: An R package that simulates multilocus models of pathogen evolution
gan: Lourenço, J, et al.
Cyhoeddwyd: (2010)

Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean
gan: Penman, B, et al.
Cyhoeddwyd: (2009)

Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean.
gan: Penman, B, et al.
Cyhoeddwyd: (2009)

Influenza outbreaks
gan: Wikramaratna, P, et al.
Cyhoeddwyd: (2009)

Influenza outbreaks.
gan: Wikramaratna, P, et al.
Cyhoeddwyd: (2009)

Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes
gan: Itoh A, et al.
Cyhoeddwyd: (2017-05-01)

A naturally protective epitope of limited variability as an influenza vaccine target
gan: Thompson, C, et al.
Cyhoeddwyd: (2018)

Understanding the contrasting spatial haplotype patterns of malaria-protective β-globin polymorphisms
gan: Hockham, C, et al.
Cyhoeddwyd: (2015)

Guest editorial: understanding dental pulp innate immunity - a basis for identifying new targets for therapeutic agents that dampen inflammation
gan: Jean-Christophe Farges
Cyhoeddwyd: (2009-06-01)

Estimating the false-negative test probability of SARS-CoV-2 by RT-PCR
gan: Wikramaratna, PS, et al.
Cyhoeddwyd: (2020)

Prediction of thioredoxin and glutaredoxin target proteins by identifying reversibly oxidized cysteinyl residues
gan: Lee Hang-mao, et al.
Cyhoeddwyd: (2010-12-01)

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets
gan: Michela Carlet, et al.
Cyhoeddwyd: (2021-09-01)

The evolution of viral diversity
gan: Wikramaratna, P
Cyhoeddwyd: (2012)

A naturally protective epitope of limited variability as an influenza vaccine target
gan: Craig P. Thompson, et al.
Cyhoeddwyd: (2018-09-01)

From Renal Biomarkers to Therapeutic Targets: The Use of Monocyte Chemoattractant Protein 1, Transforming Growth Factor-Beta, and Connective Tissue Growth Factor in Diabetic Nephropathy and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
gan: Katrina J Spensley, et al.
Cyhoeddwyd: (2018-12-01)

Protective antigens against glanders identified by expression library immunization
gan: Gregory C. Whitlock, et al.
Cyhoeddwyd: (2011-11-01)

High-Throughput Antibody Profiling Identifies Targets of Protective Immunity against <i>P. falciparum</i> Malaria in Thailand
gan: Ifra Hassan, et al.
Cyhoeddwyd: (2023-08-01)

A reverse vaccinology approach identifies putative vaccination targets in the zoonotic nematode Ascaris
gan: Francisco M. D. Evangelista, et al.
Cyhoeddwyd: (2022-11-01)

The antigenic evolution of influenza: drift or thrift?
gan: Wikramaratna, P, et al.
Cyhoeddwyd: (2013)

The effects of tertiary and quaternary infections on the epidemiology of dengue.
gan: Wikramaratna, P, et al.
Cyhoeddwyd: (2010)

The antigenic evolution of influenza: drift or thrift?
gan: Wikramaratna, P, et al.
Cyhoeddwyd: (2013)

Identifying asynchronies: Reverse trigger
gan: Víctor Perez, et al.
Cyhoeddwyd: (2022-06-01)

Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice
gan: Ayana N. Martin, et al.
Cyhoeddwyd: (2018-01-01)

Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance
gan: Jingjing Deng, et al.
Cyhoeddwyd: (2022-03-01)

Proteomic analysis of Kveim reagent identifies targets of cellular immunity in sarcoidosis
gan: Eberhardt, C, et al.
Cyhoeddwyd: (2017)

Adaptive immunity selects against malaria infection blocking mutations.
gan: Bridget S Penman, et al.
Cyhoeddwyd: (2020-10-01)