Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.
The role of lipids in atherogenesis is well established; sub-endothelial deposition of oxidised low density lipoprotein (ox-LDL) initiates atherosclerotic plaque formation. Circulating cholesterol is regulated by its dietary intake and endogenous synthesis on one hand, and its elimination from the c...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2016
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| _version_ | 1826290877050388480 |
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| author | Akoumianakis, I Antoniades, C |
| author_facet | Akoumianakis, I Antoniades, C |
| author_sort | Akoumianakis, I |
| collection | OXFORD |
| description | The role of lipids in atherogenesis is well established; sub-endothelial deposition of oxidised low density lipoprotein (ox-LDL) initiates atherosclerotic plaque formation. Circulating cholesterol is regulated by its dietary intake and endogenous synthesis on one hand, and its elimination from the circulation via LDL-receptors/excretion in the bile on the other hand.2 Various lipid-lowering therapies targeting these regulatory mechanisms are used in patients with dyslipidaemias, significant impacting cardiovascular risk. However, the residual risk after applying existing lipid-lowering strategies highlights the complexity of lipid metabolism and the necessity for broader understanding of the links between lipids and the cardiovascular system. |
| first_indexed | 2024-03-07T02:50:55Z |
| format | Journal article |
| id | oxford-uuid:ada6af48-61b7-4753-ab31-9206045479c6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:50:55Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:ada6af48-61b7-4753-ab31-9206045479c62022-03-27T03:37:06ZIs stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ada6af48-61b7-4753-ab31-9206045479c6EnglishSymplectic Elements at OxfordOxford University Press2016Akoumianakis, IAntoniades, CThe role of lipids in atherogenesis is well established; sub-endothelial deposition of oxidised low density lipoprotein (ox-LDL) initiates atherosclerotic plaque formation. Circulating cholesterol is regulated by its dietary intake and endogenous synthesis on one hand, and its elimination from the circulation via LDL-receptors/excretion in the bile on the other hand.2 Various lipid-lowering therapies targeting these regulatory mechanisms are used in patients with dyslipidaemias, significant impacting cardiovascular risk. However, the residual risk after applying existing lipid-lowering strategies highlights the complexity of lipid metabolism and the necessity for broader understanding of the links between lipids and the cardiovascular system. |
| spellingShingle | Akoumianakis, I Antoniades, C Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1. |
| title | Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1. |
| title_full | Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1. |
| title_fullStr | Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1. |
| title_full_unstemmed | Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1. |
| title_short | Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1. |
| title_sort | is stress response a new link between adipose tissue and atherogenesis the role of hsps hsf1 |
| work_keys_str_mv | AT akoumianakisi isstressresponseanewlinkbetweenadiposetissueandatherogenesistheroleofhspshsf1 AT antoniadesc isstressresponseanewlinkbetweenadiposetissueandatherogenesistheroleofhspshsf1 |