Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.

The role of lipids in atherogenesis is well established; sub-endothelial deposition of oxidised low density lipoprotein (ox-LDL) initiates atherosclerotic plaque formation. Circulating cholesterol is regulated by its dietary intake and endogenous synthesis on one hand, and its elimination from the c...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Akoumianakis, I, Antoniades, C
Materialtyp: Journal article
Språk:English
Publicerad: Oxford University Press 2016
_version_ 1826290877050388480
author Akoumianakis, I
Antoniades, C
author_facet Akoumianakis, I
Antoniades, C
author_sort Akoumianakis, I
collection OXFORD
description The role of lipids in atherogenesis is well established; sub-endothelial deposition of oxidised low density lipoprotein (ox-LDL) initiates atherosclerotic plaque formation. Circulating cholesterol is regulated by its dietary intake and endogenous synthesis on one hand, and its elimination from the circulation via LDL-receptors/excretion in the bile on the other hand.2 Various lipid-lowering therapies targeting these regulatory mechanisms are used in patients with dyslipidaemias, significant impacting cardiovascular risk. However, the residual risk after applying existing lipid-lowering strategies highlights the complexity of lipid metabolism and the necessity for broader understanding of the links between lipids and the cardiovascular system.
first_indexed 2024-03-07T02:50:55Z
format Journal article
id oxford-uuid:ada6af48-61b7-4753-ab31-9206045479c6
institution University of Oxford
language English
last_indexed 2024-03-07T02:50:55Z
publishDate 2016
publisher Oxford University Press
record_format dspace
spelling oxford-uuid:ada6af48-61b7-4753-ab31-9206045479c62022-03-27T03:37:06ZIs stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ada6af48-61b7-4753-ab31-9206045479c6EnglishSymplectic Elements at OxfordOxford University Press2016Akoumianakis, IAntoniades, CThe role of lipids in atherogenesis is well established; sub-endothelial deposition of oxidised low density lipoprotein (ox-LDL) initiates atherosclerotic plaque formation. Circulating cholesterol is regulated by its dietary intake and endogenous synthesis on one hand, and its elimination from the circulation via LDL-receptors/excretion in the bile on the other hand.2 Various lipid-lowering therapies targeting these regulatory mechanisms are used in patients with dyslipidaemias, significant impacting cardiovascular risk. However, the residual risk after applying existing lipid-lowering strategies highlights the complexity of lipid metabolism and the necessity for broader understanding of the links between lipids and the cardiovascular system.
spellingShingle Akoumianakis, I
Antoniades, C
Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.
title Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.
title_full Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.
title_fullStr Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.
title_full_unstemmed Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.
title_short Is stress response a new link between adipose tissue and atherogenesis? The role of HSPs/HSF1.
title_sort is stress response a new link between adipose tissue and atherogenesis the role of hsps hsf1
work_keys_str_mv AT akoumianakisi isstressresponseanewlinkbetweenadiposetissueandatherogenesistheroleofhspshsf1
AT antoniadesc isstressresponseanewlinkbetweenadiposetissueandatherogenesistheroleofhspshsf1