Constitutive upregulations of titin-based signalling proteins in KY deficient muscles.
An increase in the expression of stretch/stress response elements in fast and slow muscles has been previously described in a transcriptional profiling of KY deficient muscles. Here, we have characterized the induction of this titin-based family of signalling proteins in ky/ky muscles at the protein...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797088495428173824 |
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| author | Beatham, J Gehmlich, K van der Ven, P Sarparanta, J Williams, D Underhill, P Geier, C Fürst, DO Udd, B Blanco, G |
| author_facet | Beatham, J Gehmlich, K van der Ven, P Sarparanta, J Williams, D Underhill, P Geier, C Fürst, DO Udd, B Blanco, G |
| author_sort | Beatham, J |
| collection | OXFORD |
| description | An increase in the expression of stretch/stress response elements in fast and slow muscles has been previously described in a transcriptional profiling of KY deficient muscles. Here, we have characterized the induction of this titin-based family of signalling proteins in ky/ky muscles at the protein level. Changes in expression of MLP, MARP2 and Xin have been related to the onset of dystrophic and adaptive changes that operate in ky/ky muscles. Our results indicate that induction of this set of genes is an early consequence of the interference caused by the absence of the KY protein. A search of muscle profiles of mouse models revealed such molecular hallmark only in muscles subjected to a single bout of eccentric contractions and specific titin mutants. Based on the role of this family as titin-based stress response molecules, it is suggested that titin structural/signalling instability is common to ky and titin mouse mutants and eccentric contractions. |
| first_indexed | 2024-03-07T02:50:55Z |
| format | Journal article |
| id | oxford-uuid:ada7734d-327d-4d4d-9a83-9bb5a386091a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:50:55Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:ada7734d-327d-4d4d-9a83-9bb5a386091a2022-03-27T03:37:07ZConstitutive upregulations of titin-based signalling proteins in KY deficient muscles.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ada7734d-327d-4d4d-9a83-9bb5a386091aEnglishSymplectic Elements at Oxford2006Beatham, JGehmlich, Kvan der Ven, PSarparanta, JWilliams, DUnderhill, PGeier, CFürst, DOUdd, BBlanco, GAn increase in the expression of stretch/stress response elements in fast and slow muscles has been previously described in a transcriptional profiling of KY deficient muscles. Here, we have characterized the induction of this titin-based family of signalling proteins in ky/ky muscles at the protein level. Changes in expression of MLP, MARP2 and Xin have been related to the onset of dystrophic and adaptive changes that operate in ky/ky muscles. Our results indicate that induction of this set of genes is an early consequence of the interference caused by the absence of the KY protein. A search of muscle profiles of mouse models revealed such molecular hallmark only in muscles subjected to a single bout of eccentric contractions and specific titin mutants. Based on the role of this family as titin-based stress response molecules, it is suggested that titin structural/signalling instability is common to ky and titin mouse mutants and eccentric contractions. |
| spellingShingle | Beatham, J Gehmlich, K van der Ven, P Sarparanta, J Williams, D Underhill, P Geier, C Fürst, DO Udd, B Blanco, G Constitutive upregulations of titin-based signalling proteins in KY deficient muscles. |
| title | Constitutive upregulations of titin-based signalling proteins in KY deficient muscles. |
| title_full | Constitutive upregulations of titin-based signalling proteins in KY deficient muscles. |
| title_fullStr | Constitutive upregulations of titin-based signalling proteins in KY deficient muscles. |
| title_full_unstemmed | Constitutive upregulations of titin-based signalling proteins in KY deficient muscles. |
| title_short | Constitutive upregulations of titin-based signalling proteins in KY deficient muscles. |
| title_sort | constitutive upregulations of titin based signalling proteins in ky deficient muscles |
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