NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

Hyperthermia (HT) is a strong adjuvant treatment with radiotherapy and chemotherapy because it causes tumor reoxygenation. However, the detailed molecular mechanisms of how HT enhances tumor oxygenation have not been elucidated. Here we report that 1 h of HT activates hypoxia-inducible factor-1 (HIF...

Detaylı Bibliyografya
Asıl Yazarlar:	Moon, EJ, Sonveaux, P, Porporato, PE, Danhier, P, Gallez, B, Batinic-Haberle, I, Nien, Y-C, Schroeder, T, Dewhirst, MW
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	National Academy of Sciences 2010

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