Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs
Viral pathogens account for a significant proportion of the burden of emerging infectious diseases in humans. The Wellcome Trust-Vietnamese Initiative on Zoonotic Infections (WT-VIZIONS) is aiming to understand the circulation of viral zoonotic pathogens in animals that pose a potential risk to huma...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Blackwell Verlag
2017
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| _version_ | 1826290888326774784 |
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| author | Berto, A Pham, H Thao, T Vy, N Caddy, S Hiraide, R Tue, N Goodfellow, I Carrique-Mas, J Thwaites, G Baker, S Boni, M VIZIONS consortium |
| author_facet | Berto, A Pham, H Thao, T Vy, N Caddy, S Hiraide, R Tue, N Goodfellow, I Carrique-Mas, J Thwaites, G Baker, S Boni, M VIZIONS consortium |
| author_sort | Berto, A |
| collection | OXFORD |
| description | Viral pathogens account for a significant proportion of the burden of emerging infectious diseases in humans. The Wellcome Trust-Vietnamese Initiative on Zoonotic Infections (WT-VIZIONS) is aiming to understand the circulation of viral zoonotic pathogens in animals that pose a potential risk to human health. Evidence suggests that human exposure and infections with hepatitis E virus (HEV) genotypes (GT) 3 and 4 results from zoonotic transmission. Hypothesising that HEV GT3 and GT4 are circulating in the Vietnamese pig population and can be transmitted to humans, we aimed to estimate the seroprevalence of HEV exposure in a population of farmers and the general population. We additionally performed sequence analysis of HEV in pig populations in the same region to address knowledge gaps regarding HEV circulation and to evaluate if pigs were a potential source of HEV exposure. We found a high prevalence of HEV GT3 viral RNA in pigs (19.1% in faecal samples and 8.2% in rectal swabs) and a high HEV seroprevalence in pig farmers (16.0%) and a hospital-attending population (31.7%) in southern Vietnam. The hospital population was recruited as a general-population proxy even though this particular population subgroup may introduce bias. The detection of HEV RNA in pigs indicates that HEV may be a zoonotic disease risk in this location, although a larger sample size is required to infer an association between HEV positivity in pigs and seroprevalence in humans. |
| first_indexed | 2024-03-07T02:51:05Z |
| format | Journal article |
| id | oxford-uuid:adb319cc-d4e5-4d92-a795-02ba41330c9b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:51:05Z |
| publishDate | 2017 |
| publisher | Blackwell Verlag |
| record_format | dspace |
| spelling | oxford-uuid:adb319cc-d4e5-4d92-a795-02ba41330c9b2022-03-27T03:37:34ZHepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:adb319cc-d4e5-4d92-a795-02ba41330c9bEnglishSymplectic Elements at OxfordBlackwell Verlag2017Berto, APham, HThao, TVy, NCaddy, SHiraide, RTue, NGoodfellow, ICarrique-Mas, JThwaites, GBaker, SBoni, MVIZIONS consortiumViral pathogens account for a significant proportion of the burden of emerging infectious diseases in humans. The Wellcome Trust-Vietnamese Initiative on Zoonotic Infections (WT-VIZIONS) is aiming to understand the circulation of viral zoonotic pathogens in animals that pose a potential risk to human health. Evidence suggests that human exposure and infections with hepatitis E virus (HEV) genotypes (GT) 3 and 4 results from zoonotic transmission. Hypothesising that HEV GT3 and GT4 are circulating in the Vietnamese pig population and can be transmitted to humans, we aimed to estimate the seroprevalence of HEV exposure in a population of farmers and the general population. We additionally performed sequence analysis of HEV in pig populations in the same region to address knowledge gaps regarding HEV circulation and to evaluate if pigs were a potential source of HEV exposure. We found a high prevalence of HEV GT3 viral RNA in pigs (19.1% in faecal samples and 8.2% in rectal swabs) and a high HEV seroprevalence in pig farmers (16.0%) and a hospital-attending population (31.7%) in southern Vietnam. The hospital population was recruited as a general-population proxy even though this particular population subgroup may introduce bias. The detection of HEV RNA in pigs indicates that HEV may be a zoonotic disease risk in this location, although a larger sample size is required to infer an association between HEV positivity in pigs and seroprevalence in humans. |
| spellingShingle | Berto, A Pham, H Thao, T Vy, N Caddy, S Hiraide, R Tue, N Goodfellow, I Carrique-Mas, J Thwaites, G Baker, S Boni, M VIZIONS consortium Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs |
| title | Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs |
| title_full | Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs |
| title_fullStr | Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs |
| title_full_unstemmed | Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs |
| title_short | Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs |
| title_sort | hepatitis e in southern vietnam seroepidemiology in humans and molecular epidemiology in pigs |
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