Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
Asparagine-803 in the C-terminal transactivation domain of human hypoxia-inducible factor (HIF)-1 alpha-subunit is hydroxylated by factor inhibiting HIF-1 (FIH-1) under normoxic conditions causing abrogation of the HIF-1alpha/p300 interaction. NMR and other analyses of a hydroxylated HIF fragment pr...
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Detalhes bibliográficos
| Principais autores: |
McNeill, L,
Hewitson, K,
Claridge, T,
Seibel, J,
Horsfall, L,
Schofield, C |
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| Formato: | Journal article
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| Idioma: | English |
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| Publicado em: |
2002
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