Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.

Asparagine-803 in the C-terminal transactivation domain of human hypoxia-inducible factor (HIF)-1 alpha-subunit is hydroxylated by factor inhibiting HIF-1 (FIH-1) under normoxic conditions causing abrogation of the HIF-1alpha/p300 interaction. NMR and other analyses of a hydroxylated HIF fragment pr...

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Bibliografiske detaljer
Main Authors:	McNeill, L, Hewitson, K, Claridge, T, Seibel, J, Horsfall, L, Schofield, C
Format:	Journal article
Sprog:	English
Udgivet:	2002

Lignende værker

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
af: Lancaster, D, et al.
Udgivet: (2004)

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
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Udgivet: (2006)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
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Udgivet: (2002)

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
af: Cockman, M, et al.
Udgivet: (2009)

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
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Udgivet: (2011)

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
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Udgivet: (2005)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
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Udgivet: (2004)

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
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Udgivet: (2009)

Biochemical and structural insights into FIH-catalysed hydroxylation of transient receptor potential ankyrin repeat domains
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Udgivet: (2022)

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
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Udgivet: (2007)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
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Udgivet: (2016)

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
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Udgivet: (2009)

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.
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Udgivet: (2004)

Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins
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Udgivet: (2022)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
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Udgivet: (2005)

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
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Udgivet: (2011)

Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway.
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Udgivet: (2008)

Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway
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Udgivet: (2008)

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement.
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Udgivet: (2012)

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement
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Udgivet: (2012)

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
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Udgivet: (2021)

Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function.
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Udgivet: (2009)

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold.
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Udgivet: (2009)

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
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Udgivet: (2005)

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
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Udgivet: (2011)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
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Udgivet: (2012)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
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Udgivet: (2012)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
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Udgivet: (2002)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
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Udgivet: (2018)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
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Udgivet: (2019)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
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Udgivet: (2007)

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
af: Carsten C Scholz, et al.
Udgivet: (2016-01-01)

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
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Udgivet: (2007)

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
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Udgivet: (2014)

Mechanistic and structural study of human aspartate/asparagine-beta-hydroxylase
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Udgivet: (2023)

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
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Udgivet: (2020)

Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer.
af: Hewitson, K, et al.
Udgivet: (2004)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
af: Inga Pfeffer, et al.
Udgivet: (2019-10-01)

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
af: Moritz J. Strowitzki, et al.
Udgivet: (2019-04-01)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
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Udgivet: (2003)