Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease
Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes activated by bacteria that produce vitamin B2 metabolites. Mouse models of infection have demonstrated a role for MAIT cells in antimicrobial defense. However, proposed protective roles of MAIT cells in human infections remain unpr...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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National Academy of Sciences
2020
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| _version_ | 1797088561964515328 |
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| author | Preciado-Llanes, L Aulicino, A Canals, R Geros, AS Napolitani, G Simmons, A Salio, M |
| author_facet | Preciado-Llanes, L Aulicino, A Canals, R Geros, AS Napolitani, G Simmons, A Salio, M |
| author_sort | Preciado-Llanes, L |
| collection | OXFORD |
| description | Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes activated by bacteria that produce vitamin B2 metabolites. Mouse models of infection have demonstrated a role for MAIT cells in antimicrobial defense. However, proposed protective roles of MAIT cells in human infections remain unproven and clinical conditions associated with selective absence of MAIT cells have not been identified. We report that typhoidal and nontyphoidal Salmonella enterica strains activate MAIT cells. However, S. Typhimurium sequence type 313 (ST313) lineage 2 strains, which are responsible for the burden of multidrug-resistant nontyphoidal invasive disease in Africa, escape MAIT cell recognition through overexpression of ribB. This bacterial gene encodes the 4-dihydroxy-2-butanone-4-phosphate synthase enzyme of the riboflavin biosynthetic pathway. The MAIT cell-specific phenotype did not extend to other innate lymphocytes. We propose that ribB overexpression is an evolved trait that facilitates evasion from immune recognition by MAIT cells and contributes to the invasive pathogenesis of S. Typhimurium ST313 lineage 2. |
| first_indexed | 2024-03-07T02:51:51Z |
| format | Journal article |
| id | oxford-uuid:adf23508-7175-4600-8617-1f5095b75019 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:51:51Z |
| publishDate | 2020 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | oxford-uuid:adf23508-7175-4600-8617-1f5095b750192022-03-27T03:39:22ZEvasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:adf23508-7175-4600-8617-1f5095b75019EnglishSymplectic ElementsNational Academy of Sciences2020Preciado-Llanes, LAulicino, ACanals, RGeros, ASNapolitani, GSimmons, ASalio, MMucosal-associated invariant T (MAIT) cells are innate T lymphocytes activated by bacteria that produce vitamin B2 metabolites. Mouse models of infection have demonstrated a role for MAIT cells in antimicrobial defense. However, proposed protective roles of MAIT cells in human infections remain unproven and clinical conditions associated with selective absence of MAIT cells have not been identified. We report that typhoidal and nontyphoidal Salmonella enterica strains activate MAIT cells. However, S. Typhimurium sequence type 313 (ST313) lineage 2 strains, which are responsible for the burden of multidrug-resistant nontyphoidal invasive disease in Africa, escape MAIT cell recognition through overexpression of ribB. This bacterial gene encodes the 4-dihydroxy-2-butanone-4-phosphate synthase enzyme of the riboflavin biosynthetic pathway. The MAIT cell-specific phenotype did not extend to other innate lymphocytes. We propose that ribB overexpression is an evolved trait that facilitates evasion from immune recognition by MAIT cells and contributes to the invasive pathogenesis of S. Typhimurium ST313 lineage 2. |
| spellingShingle | Preciado-Llanes, L Aulicino, A Canals, R Geros, AS Napolitani, G Simmons, A Salio, M Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease |
| title | Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease |
| title_full | Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease |
| title_fullStr | Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease |
| title_full_unstemmed | Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease |
| title_short | Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease |
| title_sort | evasion of mait cell recognition by the african salmonella typhimurium st313 pathovar that causes invasive disease |
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