Artemisinin: large community studies.
Prospective randomized trials with oral artemisinin derivatives have been conducted in over 1000 patients to determine the optimum treatment of multi-drug resistant falciparum malaria on the Thai-Burmese border. These drugs have proved valuable in 3 settings. (i) Primary treatment of uncomplicated m...
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
1994
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| _version_ | 1826290961493262336 |
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| author | Nosten, F |
| author_facet | Nosten, F |
| author_sort | Nosten, F |
| collection | OXFORD |
| description | Prospective randomized trials with oral artemisinin derivatives have been conducted in over 1000 patients to determine the optimum treatment of multi-drug resistant falciparum malaria on the Thai-Burmese border. These drugs have proved valuable in 3 settings. (i) Primary treatment of uncomplicated malaria in combination with mefloquine, when they accelerate the rate of recovery, eliminate the risk of dangerous early failures, and if given for 3 d or more improve overall cure rates; (ii) treatment of recrudescent infections, which otherwise have a high failure rate; and (iii) oral treatment of patients with high parasitaemias (> or = 4%) but no clinical evidence of severity (a group who would usually receive parenteral quinine). The parenteral formulation of artemether is absorbed if given rectally, and this may offer a practical alternative method of treating severe malaria in rural areas. |
| first_indexed | 2024-03-07T02:52:12Z |
| format | Journal article |
| id | oxford-uuid:ae0bd3ad-cd26-4b86-85dc-73a37b6fe406 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:52:12Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:ae0bd3ad-cd26-4b86-85dc-73a37b6fe4062022-03-27T03:39:59ZArtemisinin: large community studies.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ae0bd3ad-cd26-4b86-85dc-73a37b6fe406EnglishSymplectic Elements at Oxford1994Nosten, FProspective randomized trials with oral artemisinin derivatives have been conducted in over 1000 patients to determine the optimum treatment of multi-drug resistant falciparum malaria on the Thai-Burmese border. These drugs have proved valuable in 3 settings. (i) Primary treatment of uncomplicated malaria in combination with mefloquine, when they accelerate the rate of recovery, eliminate the risk of dangerous early failures, and if given for 3 d or more improve overall cure rates; (ii) treatment of recrudescent infections, which otherwise have a high failure rate; and (iii) oral treatment of patients with high parasitaemias (> or = 4%) but no clinical evidence of severity (a group who would usually receive parenteral quinine). The parenteral formulation of artemether is absorbed if given rectally, and this may offer a practical alternative method of treating severe malaria in rural areas. |
| spellingShingle | Nosten, F Artemisinin: large community studies. |
| title | Artemisinin: large community studies. |
| title_full | Artemisinin: large community studies. |
| title_fullStr | Artemisinin: large community studies. |
| title_full_unstemmed | Artemisinin: large community studies. |
| title_short | Artemisinin: large community studies. |
| title_sort | artemisinin large community studies |
| work_keys_str_mv | AT nostenf artemisininlargecommunitystudies |