Antibodies expose multiple weaknesses in the glycan shield of HIV.

A shield of glycans coat the viral envelope proteins of the human immunodeficiency virus (HIV). Broadly neutralising antibodies can recognise this shield despite structural variation in these ‘self’ carbohydrate structures.

Detalhes bibliográficos
Principais autores: Crispin, M, Bowden, T
Formato: Journal article
Idioma:English
Publicado em: Nature Publishing Group 2013
Descrição
Resumo:A shield of glycans coat the viral envelope proteins of the human immunodeficiency virus (HIV). Broadly neutralising antibodies can recognise this shield despite structural variation in these ‘self’ carbohydrate structures.