Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.

Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.

Thymic T cell development is dependent on a specialized epithelial microenvironment mainly composed of cortical and medullary thymic epithelial cells (TECs). The molecular programs governing the differentiation and maintenance of TECs remain largely unknown. Wnt signaling is central to the developme...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Zuklys, S, Gill, J, Keller, M, Hauri-Hohl, M, Zhanybekova, S, Balciunaite, G, Na, K, Jeker, LT, Hafen, K, Tsukamoto, N, Amagai, T, Taketo, M, Krenger, W, Holländer, G
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2009

Eitemau Tebyg

Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.
gan: Jeker, LT, et al.
Cyhoeddwyd: (2008)

Loss of thymus epithelial cell identity following the constitutive activation of the canonical Wnt pathway
gan: Zuklys, S, et al.
Cyhoeddwyd: (2007)

TGF- 2signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution
gan: Hauri-Hohl, M, et al.
Cyhoeddwyd: (2008)

TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.
gan: Hauri-Hohl, M, et al.
Cyhoeddwyd: (2008)

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.
gan: Hauri-Hohl, M, et al.
Cyhoeddwyd: (2007)

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.
gan: Hauri-Hohl, M, et al.
Cyhoeddwyd: (2014)

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla
gan: Hauri-Hohl, M, et al.
Cyhoeddwyd: (2014)

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.
gan: Rossi, S, et al.
Cyhoeddwyd: (2007)

Epithelial cytoprotection sustains ectopic expression of tissue-restricted antigens in the thymus during murine acute GVHD.
gan: Dertschnig, S, et al.
Cyhoeddwyd: (2013)

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation
gan: Keller, M, et al.
Cyhoeddwyd: (2007)

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.
gan: Žuklys, S, et al.
Cyhoeddwyd: (2016)

Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development
gan: Žuklys, S, et al.
Cyhoeddwyd: (2016)

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.
gan: Ohigashi, I, et al.
Cyhoeddwyd: (2013)

Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla
gan: Mayer, C, et al.
Cyhoeddwyd: (2016)

The immunopathology of thymic GVHD.
gan: Krenger, W, et al.
Cyhoeddwyd: (2008)

The thymus in GVHD pathophysiology.
gan: Krenger, W, et al.
Cyhoeddwyd: (2008)

TGF-beta signalling contributes to thymic epithelial cell damage and regeneration following myeloablative conditioning and stem-cell transplantation
gan: Hauri-Hohl MM, et al.
Cyhoeddwyd: (2008-09-01)

Comprehensively profiling the chromatin architecture of tissue restricted antigen expression in thymic epithelial cells over development
gan: Handel, A, et al.
Cyhoeddwyd: (2018)

A short primer on early molecular and cellular events in thymus organogenesis and replacement.
gan: Barthlott, T, et al.
Cyhoeddwyd: (2007)

The role of the thymus in allogeneic haematopoietic stem cell transplantation
gan: Krenger, W, et al.
Cyhoeddwyd: (2010)

The role of the thymus in allogeneic hematopoietic stem cell transplantation.
gan: Krenger, W, et al.
Cyhoeddwyd: (2010)

Emerging strategies to boost thymic function.
gan: Holländer, G, et al.
Cyhoeddwyd: (2010)

Thymic T-cell development in allogeneic stem cell transplantation.
gan: Krenger, W, et al.
Cyhoeddwyd: (2011)

TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.
gan: Odaka, C, et al.
Cyhoeddwyd: (2013)

Thymus extracellular matrix-derived scaffolds support graft-resident thymopoiesis and long-term in vitro culture of adult thymic epithelial cells
gan: Asnaghi, MA, et al.
Cyhoeddwyd: (2021)

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2
gan: Barthlott, T, et al.
Cyhoeddwyd: (2021)

Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development
gan: Adam E. Handel, et al.
Cyhoeddwyd: (2018-09-01)

MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.
gan: Zuklys, S, et al.
Cyhoeddwyd: (2012)

Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development
gan: Sayumi Fujimori, et al.
Cyhoeddwyd: (2022-01-01)

Thymus gland and thymic dysfunctions in children
gan: Tamara Turcanu, et al.
Cyhoeddwyd: (2024-06-01)

Thymic cysts originate from Foxn1 positive thymic medullary epithelium.
gan: Vroegindeweij, E, et al.
Cyhoeddwyd: (2010)

Novel Combination of Surface Markers for the Reliable and Comprehensive Identification of Human Thymic Epithelial Cells by Flow Cytometry: Quantitation and Transcriptional Characterization of Thymic Stroma in a Pediatric Cohort
gan: Veronika Haunerdinger, et al.
Cyhoeddwyd: (2021-09-01)

The role of the thymus in allogeneic haematopoietic stem cell transplantation
gan: Krenger, W, et al.
Cyhoeddwyd: (2010)

Delta-like 4 is indispensable in thymic environment specific for T cell development.
gan: Hozumi, K, et al.
Cyhoeddwyd: (2008)

Positive and Negative Selection in the Thymus and the Thymic Paradox
gan: Julie N. Reza, et al.
Cyhoeddwyd: (1998-01-01)

Insights into Thymus Development and Viral Thymic Infections
gan: Francesco Albano, et al.
Cyhoeddwyd: (2019-09-01)

IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.
gan: Shitara, S, et al.
Cyhoeddwyd: (2013)

Alterations of Thymic Epithelial Cells in Lipopolysaccharide-induced Neonatal Thymus Involution
gan: Yong-Jie Zhou, et al.
Cyhoeddwyd: (2016-01-01)

Editorial: Thymus function and aging: A focus on thymic epithelial cells
gan: Valentin P. Shichkin, et al.
Cyhoeddwyd: (2022-08-01)

Thymus ad astra, or spaceflight-induced thymic involution
gan: Wataru Muramatsu, et al.
Cyhoeddwyd: (2025-01-01)