Salmonella Typhi and Paratyphi A infections in Cambodian children, 2012 - 2016
<br><strong>Objectives: </strong>Enteric fever remains an important diagnostic and treatment challenge in febrile children living in the tropics. In the context of a national Salmonella enterica serovar Paratyphi A outbreak, the objective of this retrospective study was to compare...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2020
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| _version_ | 1797109184704020480 |
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| author | Kheng, C Meas, V Pen, S Sar, P Turner, P |
| author_facet | Kheng, C Meas, V Pen, S Sar, P Turner, P |
| author_sort | Kheng, C |
| collection | OXFORD |
| description | <br><strong>Objectives: </strong>Enteric fever remains an important diagnostic and treatment challenge in febrile children
living in the tropics. In the context of a national Salmonella enterica serovar Paratyphi A outbreak, the
objective of this retrospective study was to compare features of S. Typhi and S. Paratyphi A infections in
Cambodian children.</br>
<br><strong>Methods: </strong>Clinical and laboratory features were reviewed for 192 blood culture-confirmed children with S. Typhi and S. Paratyphi A infections presenting to a paediatric referral hospital in Siem Reap, 2012–2016.</br>
<br><strong>Results: </strong>Children with S. Typhi infections were younger, were more likely to have chills and/or diarrhoea,
and were more frequently hospitalized than those with S. Paratyphi A infections. Over three quarters
(88.3%) of S. Typhi isolates were multidrug-resistant, compared to none of the S. Paratyphi A.</br>
<br><strong>Conclusions: </strong>In this small study of Cambodian children, S. Typhi infections were more severe than S.
Paratyphi A infections. Antibiotic resistance limits treatment options for enteric fever in this population.</br> |
| first_indexed | 2024-03-07T07:36:48Z |
| format | Journal article |
| id | oxford-uuid:ae11fe98-5b5b-478b-830b-b820aabae0fa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:36:48Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:ae11fe98-5b5b-478b-830b-b820aabae0fa2023-03-17T09:34:37ZSalmonella Typhi and Paratyphi A infections in Cambodian children, 2012 - 2016Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ae11fe98-5b5b-478b-830b-b820aabae0faEnglishSymplectic ElementsElsevier2020Kheng, CMeas, VPen, SSar, PTurner, P<br><strong>Objectives: </strong>Enteric fever remains an important diagnostic and treatment challenge in febrile children living in the tropics. In the context of a national Salmonella enterica serovar Paratyphi A outbreak, the objective of this retrospective study was to compare features of S. Typhi and S. Paratyphi A infections in Cambodian children.</br> <br><strong>Methods: </strong>Clinical and laboratory features were reviewed for 192 blood culture-confirmed children with S. Typhi and S. Paratyphi A infections presenting to a paediatric referral hospital in Siem Reap, 2012–2016.</br> <br><strong>Results: </strong>Children with S. Typhi infections were younger, were more likely to have chills and/or diarrhoea, and were more frequently hospitalized than those with S. Paratyphi A infections. Over three quarters (88.3%) of S. Typhi isolates were multidrug-resistant, compared to none of the S. Paratyphi A.</br> <br><strong>Conclusions: </strong>In this small study of Cambodian children, S. Typhi infections were more severe than S. Paratyphi A infections. Antibiotic resistance limits treatment options for enteric fever in this population.</br> |
| spellingShingle | Kheng, C Meas, V Pen, S Sar, P Turner, P Salmonella Typhi and Paratyphi A infections in Cambodian children, 2012 - 2016 |
| title | Salmonella Typhi and Paratyphi A infections in Cambodian children, 2012 - 2016 |
| title_full | Salmonella Typhi and Paratyphi A infections in Cambodian children, 2012 - 2016 |
| title_fullStr | Salmonella Typhi and Paratyphi A infections in Cambodian children, 2012 - 2016 |
| title_full_unstemmed | Salmonella Typhi and Paratyphi A infections in Cambodian children, 2012 - 2016 |
| title_short | Salmonella Typhi and Paratyphi A infections in Cambodian children, 2012 - 2016 |
| title_sort | salmonella typhi and paratyphi a infections in cambodian children 2012 2016 |
| work_keys_str_mv | AT khengc salmonellatyphiandparatyphiainfectionsincambodianchildren20122016 AT measv salmonellatyphiandparatyphiainfectionsincambodianchildren20122016 AT pens salmonellatyphiandparatyphiainfectionsincambodianchildren20122016 AT sarp salmonellatyphiandparatyphiainfectionsincambodianchildren20122016 AT turnerp salmonellatyphiandparatyphiainfectionsincambodianchildren20122016 |