Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.

Dilated cardiomyopathy (DCM), characterized by cardiac dilatation and contractile dysfunction, is a major cause of heart failure. Inherited DCM can result from mutations in the genes encoding cardiac troponin T, troponin C, and alpha-tropomyosin; different mutations in the same genes cause hypertrop...

Полное описание

Библиографические подробности
Главные авторы: Mirza, M, Marston, S, Willott, R, Ashley, C, Mogensen, J, McKenna, W, Robinson, P, Redwood, C, Watkins, H
Формат: Journal article
Язык:English
Опубликовано: 2005