Amylin in bone conservation current evidence and hypothetical Considerations.
Amylin, a 37-amino-acid long single-chain polypeptide, is structurally homologous to calcitonin and calcitonin gene-related peptide (CGRP). The peptide is secreted from pancreatic beta cells and is thought to have an anti-insulin action. Here, we review the recently described effects of amylin on ca...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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| _version_ | 1797088610481078272 |
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| author | Zaidi, M Shankar, V Huang, C Pazianas, M Bloom, SR |
| author_facet | Zaidi, M Shankar, V Huang, C Pazianas, M Bloom, SR |
| author_sort | Zaidi, M |
| collection | OXFORD |
| description | Amylin, a 37-amino-acid long single-chain polypeptide, is structurally homologous to calcitonin and calcitonin gene-related peptide (CGRP). The peptide is secreted from pancreatic beta cells and is thought to have an anti-insulin action. Here, we review the recently described effects of amylin on calcium homeostasis and discuss its possible role in bone conservation. Amylin is a potent hypocalcemic and antiresorptive peptide. Studies using isolated osteoclasts have revealed that amylin inhibits cell motility (Q effect), without affecting cell spread area or elevating cytosolic [Ca(2+)]. Thus, amylin action is similar to that of calcitonin, but lower in potency. Lower circulating concentrations of amylin in type-1 diabetes may cause the bone loss associated with this condition. |
| first_indexed | 2024-03-07T02:52:34Z |
| format | Journal article |
| id | oxford-uuid:ae2c6270-c055-494f-9741-996c7ad5f586 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:52:34Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:ae2c6270-c055-494f-9741-996c7ad5f5862022-03-27T03:40:49ZAmylin in bone conservation current evidence and hypothetical Considerations.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ae2c6270-c055-494f-9741-996c7ad5f586EnglishSymplectic Elements at Oxford1993Zaidi, MShankar, VHuang, CPazianas, MBloom, SRAmylin, a 37-amino-acid long single-chain polypeptide, is structurally homologous to calcitonin and calcitonin gene-related peptide (CGRP). The peptide is secreted from pancreatic beta cells and is thought to have an anti-insulin action. Here, we review the recently described effects of amylin on calcium homeostasis and discuss its possible role in bone conservation. Amylin is a potent hypocalcemic and antiresorptive peptide. Studies using isolated osteoclasts have revealed that amylin inhibits cell motility (Q effect), without affecting cell spread area or elevating cytosolic [Ca(2+)]. Thus, amylin action is similar to that of calcitonin, but lower in potency. Lower circulating concentrations of amylin in type-1 diabetes may cause the bone loss associated with this condition. |
| spellingShingle | Zaidi, M Shankar, V Huang, C Pazianas, M Bloom, SR Amylin in bone conservation current evidence and hypothetical Considerations. |
| title | Amylin in bone conservation current evidence and hypothetical Considerations. |
| title_full | Amylin in bone conservation current evidence and hypothetical Considerations. |
| title_fullStr | Amylin in bone conservation current evidence and hypothetical Considerations. |
| title_full_unstemmed | Amylin in bone conservation current evidence and hypothetical Considerations. |
| title_short | Amylin in bone conservation current evidence and hypothetical Considerations. |
| title_sort | amylin in bone conservation current evidence and hypothetical considerations |
| work_keys_str_mv | AT zaidim amylininboneconservationcurrentevidenceandhypotheticalconsiderations AT shankarv amylininboneconservationcurrentevidenceandhypotheticalconsiderations AT huangc amylininboneconservationcurrentevidenceandhypotheticalconsiderations AT pazianasm amylininboneconservationcurrentevidenceandhypotheticalconsiderations AT bloomsr amylininboneconservationcurrentevidenceandhypotheticalconsiderations |