Viral infection and iron metabolism.
Fundamental cellular operations, including DNA synthesis and the generation of ATP, require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron-replete host. Some viruses selectively infect iron-acquiring cells by binding to transferrin receptor 1 during cell en...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797088622639316992 |
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| author | Drakesmith, H Prentice, A |
| author_facet | Drakesmith, H Prentice, A |
| author_sort | Drakesmith, H |
| collection | OXFORD |
| description | Fundamental cellular operations, including DNA synthesis and the generation of ATP, require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron-replete host. Some viruses selectively infect iron-acquiring cells by binding to transferrin receptor 1 during cell entry. Other viruses alter the expression of proteins involved in iron homeostasis, such as HFE and hepcidin. In HIV-1 and hepatitis C virus infections, iron overload is associated with poor prognosis and could be partly caused by the viruses themselves. Understanding how iron metabolism and viral infection interact might suggest new methods to control disease. |
| first_indexed | 2024-03-07T02:52:45Z |
| format | Journal article |
| id | oxford-uuid:ae3dade1-83fe-4a9b-b87f-59a1eafc26d5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:52:45Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:ae3dade1-83fe-4a9b-b87f-59a1eafc26d52022-03-27T03:41:10ZViral infection and iron metabolism.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ae3dade1-83fe-4a9b-b87f-59a1eafc26d5EnglishSymplectic Elements at Oxford2008Drakesmith, HPrentice, AFundamental cellular operations, including DNA synthesis and the generation of ATP, require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron-replete host. Some viruses selectively infect iron-acquiring cells by binding to transferrin receptor 1 during cell entry. Other viruses alter the expression of proteins involved in iron homeostasis, such as HFE and hepcidin. In HIV-1 and hepatitis C virus infections, iron overload is associated with poor prognosis and could be partly caused by the viruses themselves. Understanding how iron metabolism and viral infection interact might suggest new methods to control disease. |
| spellingShingle | Drakesmith, H Prentice, A Viral infection and iron metabolism. |
| title | Viral infection and iron metabolism. |
| title_full | Viral infection and iron metabolism. |
| title_fullStr | Viral infection and iron metabolism. |
| title_full_unstemmed | Viral infection and iron metabolism. |
| title_short | Viral infection and iron metabolism. |
| title_sort | viral infection and iron metabolism |
| work_keys_str_mv | AT drakesmithh viralinfectionandironmetabolism AT prenticea viralinfectionandironmetabolism |