Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients.
To avoid an unnecessary extend of surgery in primary central nervous system lymphoma (PCNSL), the diagnosis should be suspected after MRI. Pre-treatment MRI examinations of 100 immunologically competent patients with biopsy-proven PCNSL were evaluated. All patients had T2- and T1-weighted images wit...
| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
2005
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| _version_ | 1826291000950128640 |
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| author | Küker, W Nägele, T Korfel, A Heckl, S Thiel, E Bamberg, M Weller, M Herrlinger, U |
| author_facet | Küker, W Nägele, T Korfel, A Heckl, S Thiel, E Bamberg, M Weller, M Herrlinger, U |
| author_sort | Küker, W |
| collection | OXFORD |
| description | To avoid an unnecessary extend of surgery in primary central nervous system lymphoma (PCNSL), the diagnosis should be suspected after MRI. Pre-treatment MRI examinations of 100 immunologically competent patients with biopsy-proven PCNSL were evaluated. All patients had T2- and T1-weighted images with contrast enhancement. Diffusion-weighted MRI (DW-MRI) was available in 15, proton-MR-spectroscopy (1H-MRS) in four patients. The number of lesions ranged from one (n=65 patients) to eight (n=1) with a mean of 1.7. The most frequent locations were the cerebral hemispheres (n=66), the basal ganglia (n=27) and the corpus callosum (n=24). In the 65 patients with a solitary lesion, hemispheric lesions were most frequent (n=23) followed by corpus callosum (n=18). Contrast enhancement was found in all but one patient. 1H-MRS revealed a uniformly pathologic pattern of metabolite concentrations in all patients. Characteristic imaging features of PCNSL are contrast-enhancing lesions with a diameter of at least 15 mm in contact with the subarachnoid space. DW-MRI and proton spectroscopy may aid in differential diagnosis. |
| first_indexed | 2024-03-07T02:52:48Z |
| format | Journal article |
| id | oxford-uuid:ae41baa6-c735-4cfd-bc6c-6ce1a1a611f9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:52:48Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:ae41baa6-c735-4cfd-bc6c-6ce1a1a611f92022-03-27T03:41:21ZPrimary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ae41baa6-c735-4cfd-bc6c-6ce1a1a611f9EnglishSymplectic Elements at Oxford2005Küker, WNägele, TKorfel, AHeckl, SThiel, EBamberg, MWeller, MHerrlinger, UTo avoid an unnecessary extend of surgery in primary central nervous system lymphoma (PCNSL), the diagnosis should be suspected after MRI. Pre-treatment MRI examinations of 100 immunologically competent patients with biopsy-proven PCNSL were evaluated. All patients had T2- and T1-weighted images with contrast enhancement. Diffusion-weighted MRI (DW-MRI) was available in 15, proton-MR-spectroscopy (1H-MRS) in four patients. The number of lesions ranged from one (n=65 patients) to eight (n=1) with a mean of 1.7. The most frequent locations were the cerebral hemispheres (n=66), the basal ganglia (n=27) and the corpus callosum (n=24). In the 65 patients with a solitary lesion, hemispheric lesions were most frequent (n=23) followed by corpus callosum (n=18). Contrast enhancement was found in all but one patient. 1H-MRS revealed a uniformly pathologic pattern of metabolite concentrations in all patients. Characteristic imaging features of PCNSL are contrast-enhancing lesions with a diameter of at least 15 mm in contact with the subarachnoid space. DW-MRI and proton spectroscopy may aid in differential diagnosis. |
| spellingShingle | Küker, W Nägele, T Korfel, A Heckl, S Thiel, E Bamberg, M Weller, M Herrlinger, U Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. |
| title | Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. |
| title_full | Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. |
| title_fullStr | Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. |
| title_full_unstemmed | Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. |
| title_short | Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. |
| title_sort | primary central nervous system lymphomas pcnsl mri features at presentation in 100 patients |
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