Identification of syntaxin 1A as a novel binding protein for presenilin-1.

Identification of syntaxin 1A as a novel binding protein for presenilin-1.

Mutations in the presenilin 1 gene have been shown to result in Alzheimer's disease. Presenilin 1 is a multi-transmembrane protein with a large hydrophilic loop near the C-terminus. This region is required for known functions of presenilin 1. We have constrained this loop within the active site...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Smith, S, Anderson, H, Yu, G, Robertson, A, Allen, S, Tyler, S, Naylor, R, Mason, G, Wilcock, G, Roche, P, Fraser, P, Dawbarn, D
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2000

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ανά: Allen, S, κ.ά.
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ανά: Allen, S, κ.ά.
Έκδοση: (2001)

Identification and structure of the nerve growth factor binding site on TrkA.
ανά: Robertson, A, κ.ά.
Έκδοση: (2001)

A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4.
ανά: Naylor, R, κ.ά.
Έκδοση: (2002)

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ανά: Robertson, A, κ.ά.
Έκδοση: (2000)

Presenilin-1 polymorphism and Alzheimer's disease. The UK Alzheimer's Disease Collaborative Group.
ανά: Kehoe, P, κ.ά.
Έκδοση: (1996)

Presenilin-1 polymorphism and Alzheimer's disease [6]
ανά: Kehoe, P, κ.ά.
Έκδοση: (1996)

Epilepsy, Behavioral Abnormalities, and Physiological Comorbidities in Syntaxin-Binding Protein 1 (STXBP1) Mutant Zebrafish.
ανά: Brian P Grone, κ.ά.
Έκδοση: (2016-01-01)

Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor.
ανά: Holden, P, κ.ά.
Έκδοση: (1997)

Changes in alpha- and beta-secretase in Alzheimer's disease
ανά: Tyler, S, κ.ά.
Έκδοση: (2003)

alpha- and beta-secretase: profound changes in Alzheimer's disease.
ανά: Tyler, S, κ.ά.
Έκδοση: (2002)

NERVE GROWTH-FACTOR RECEPTOR-BINDING IN NORMAL AND ALZHEIMERS-DISEASE BASAL FOREBRAIN
ανά: Treanor, J, κ.ά.
Έκδοση: (1990)

EFFECTS OF SYNTAXIN BINDING PROTEIN-1 MUTATIONS IN NEURONAL NETWORK ACTIVITY AND SYNAPTIC FUNCTION
ανά: Ferenc Deak, κ.ά.
Έκδοση: (2023-10-01)

Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype.
ανά: Allen, S, κ.ά.
Έκδοση: (1997)

Presenilin-1 intron 8 polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease.
ανά: Tysoe, C, κ.ά.
Έκδοση: (1997)

The Presenilins and Alzheimer Disease
ανά: G. Lévesque, κ.ά.
Έκδοση: (2020-12-01)

The syntaxin-binding protein STXBP5 regulates progerin expression
ανά: Hongqian Qi, κ.ά.
Έκδοση: (2024-10-01)

Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain.
ανά: Treanor, J, κ.ά.
Έκδοση: (1991)

Syntaxin 1B, but not syntaxin 1A, is necessary for the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapses.
ανά: Tatsuya Mishima, κ.ά.
Έκδοση: (2014-01-01)

Morphometric immunochemical analysis of neurons in the nucleus basalis of Meynert in Alzheimer's disease.
ανά: Allen, S, κ.ά.
Έκδοση: (1988)

Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease.
ανά: Allen, S, κ.ά.
Έκδοση: (1999)

The Habc domain of syntaxin 3 is a ubiquitin binding domain
ανά: Adrian J. Giovannone, κ.ά.
Έκδοση: (2020-12-01)

Dynamic conformational changes in munc18 prevent syntaxin binding.
ανά: Dana Bar-On, κ.ά.
Έκδοση: (2011-03-01)

Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8*[S]
ανά: Yuhong He, κ.ά.
Έκδοση: (2009-03-01)

Syntaxin binding protein 1 is not required for allergic inflammation via IgE-mediated mast cell activation.
ανά: Zhengli Wu, κ.ά.
Έκδοση: (2013-01-01)

Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18.
ανά: Paola G Camoletto, κ.ά.
Έκδοση: (2009-01-01)

Functional Phenotype in Transgenic Mice Expressing Mutant Human Presenilin-1
ανά: Paul A. Barrow, κ.ά.
Έκδοση: (2000-04-01)

A presenilin-1 truncating mutation is present in two cases with autopsy-confirmed early-onset Alzheimer disease.
ανά: Tysoe, C, κ.ά.
Έκδοση: (1998)

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ανά: Fausto Ulloa, κ.ά.
Έκδοση: (2015-01-01)

Identification of a novel family of presenilin homologues.
ανά: Ponting, C, κ.ά.
Έκδοση: (2002)

Identification of an archaeal presenilin-like intramembrane protease.
ανά: Celia Torres-Arancivia, κ.ά.
Έκδοση: (2010-01-01)

Docking of secretory vesicles is syntaxin dependent.
ανά: Heidi de Wit, κ.ά.
Έκδοση: (2006-12-01)

Syntaxin4 interacting protein (Synip) binds phosphatidylinositol (3,4,5) triphosphate.
ανά: Tsugumichi Saito, κ.ά.
Έκδοση: (2012-01-01)

Measurement of pre- and post-synaptic proteins in cerebral cortex: effects of post-mortem delay.
ανά: Siew, L, κ.ά.
Έκδοση: (2004)

Dynamical Organization of Syntaxin-1A at the Presynaptic Active Zone.
ανά: Alexander Ullrich, κ.ά.
Έκδοση: (2015-09-01)

Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP
ανά: Gopal Thinakaran, κ.ά.
Έκδοση: (1998-01-01)

Presenilin-dependent intramembrane cleavage of ephrin-B1
ανά: Tomita Taisuke, κ.ά.
Έκδοση: (2006-06-01)

NERVE GROWTH-FACTOR AND OTHER NEUROTROPHINS IN ALZHEIMERS-DISEASE
ανά: Wilcock, G, κ.ά.
Έκδοση: (1994)

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ανά: Reshma Mary Martiz, κ.ά.
Έκδοση: (2022-01-01)

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