Identification of syntaxin 1A as a novel binding protein for presenilin-1.

Identification of syntaxin 1A as a novel binding protein for presenilin-1.

Mutations in the presenilin 1 gene have been shown to result in Alzheimer's disease. Presenilin 1 is a multi-transmembrane protein with a large hydrophilic loop near the C-terminus. This region is required for known functions of presenilin 1. We have constrained this loop within the active site...

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Detalles Bibliográficos
Main Authors: Smith, S, Anderson, H, Yu, G, Robertson, A, Allen, S, Tyler, S, Naylor, R, Mason, G, Wilcock, G, Roche, P, Fraser, P, Dawbarn, D
Formato: Journal article
Idioma:English
Publicado: 2000

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