Identification of syntaxin 1A as a novel binding protein for presenilin-1.

Mutations in the presenilin 1 gene have been shown to result in Alzheimer's disease. Presenilin 1 is a multi-transmembrane protein with a large hydrophilic loop near the C-terminus. This region is required for known functions of presenilin 1. We have constrained this loop within the active site...

詳細記述

書誌詳細
主要な著者: Smith, S, Anderson, H, Yu, G, Robertson, A, Allen, S, Tyler, S, Naylor, R, Mason, G, Wilcock, G, Roche, P, Fraser, P, Dawbarn, D
フォーマット: Journal article
言語:English
出版事項: 2000