TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin.
TSG-6 (the product of tumor necrosis factor [TNF]-stimulated gene 6) has a potent inhibitory effect on RANKL-mediated bone erosion. The aim of this study was to compare the activity of TSG-6 with that of osteoprotegerin (OPG) and to investigate its role as an autocrine modulator of cytokine-mediated...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1826291077445844992 |
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| author | Mahoney, D Swales, C Athanasou, N Bombardieri, M Pitzalis, C Kliskey, K Sharif, M Day, A Milner, C Sabokbar, A |
| author_facet | Mahoney, D Swales, C Athanasou, N Bombardieri, M Pitzalis, C Kliskey, K Sharif, M Day, A Milner, C Sabokbar, A |
| author_sort | Mahoney, D |
| collection | OXFORD |
| description | TSG-6 (the product of tumor necrosis factor [TNF]-stimulated gene 6) has a potent inhibitory effect on RANKL-mediated bone erosion. The aim of this study was to compare the activity of TSG-6 with that of osteoprotegerin (OPG) and to investigate its role as an autocrine modulator of cytokine-mediated osteoclast formation/activation. We also determined TSG-6 expression in inflammatory joint disease. |
| first_indexed | 2024-03-07T02:53:58Z |
| format | Journal article |
| id | oxford-uuid:aea4bee7-e7c8-473c-8761-866bdd55606b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:53:58Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:aea4bee7-e7c8-473c-8761-866bdd55606b2022-03-27T03:44:00ZTSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aea4bee7-e7c8-473c-8761-866bdd55606bEnglishSymplectic Elements at Oxford2011Mahoney, DSwales, CAthanasou, NBombardieri, MPitzalis, CKliskey, KSharif, MDay, AMilner, CSabokbar, ATSG-6 (the product of tumor necrosis factor [TNF]-stimulated gene 6) has a potent inhibitory effect on RANKL-mediated bone erosion. The aim of this study was to compare the activity of TSG-6 with that of osteoprotegerin (OPG) and to investigate its role as an autocrine modulator of cytokine-mediated osteoclast formation/activation. We also determined TSG-6 expression in inflammatory joint disease. |
| spellingShingle | Mahoney, D Swales, C Athanasou, N Bombardieri, M Pitzalis, C Kliskey, K Sharif, M Day, A Milner, C Sabokbar, A TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin. |
| title | TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin. |
| title_full | TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin. |
| title_fullStr | TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin. |
| title_full_unstemmed | TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin. |
| title_short | TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin. |
| title_sort | tsg 6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin |
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