Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome

Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome

Hepatitis C virus (HCV)-specific T cell responses are critical for immune control of infection. Viral adaptation to these responses, via mutations within regions of the virus targeted by CD8+ T cells, is associated with viral persistence. However, identifying viral adaptation to HCV-specific CD4+ T...

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Dettagli Bibliografici
Autori principali:	Lucas, M, Deshpande, P, James, I, Rauch, A, Pfafferott, K, Gaylard, E, Merani, S, Plauzolles, A, Lucas, A, McDonnell, W, Kalams, S, Pilkinton, M, Chastain, C, Barnett, L, Prosser, A, Mallal, S, Fitzmaurice, K, Drummer, H, Ansari, M, Pedergnana, V, Barnes, E, John, M, Kelleher, D, Klenerman, P, Gaudieri, S
Natura:	Journal article
Lingua:	English
Pubblicazione:	Nature Publishing Group 2018

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