The future of the RTS,S/AS01 malaria vaccine: an alternative development plan
RTS,S/AS01 is the falciparum malaria vaccine candidate that is most advanced in development, globally.<br/> In a large clinical trial in sub-Saharan African children, the protection conferred by RTS,S/AS01 was found to rapidly decline, particularly in infants. <br/>Although RTS,S/AS01 wa...
| Päätekijät: | , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
Public Library of Science
2015
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| _version_ | 1826291122857574400 |
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| author | Gosling, R von Seidlein, L |
| author_facet | Gosling, R von Seidlein, L |
| author_sort | Gosling, R |
| collection | OXFORD |
| description | RTS,S/AS01 is the falciparum malaria vaccine candidate that is most advanced in development, globally.<br/> In a large clinical trial in sub-Saharan African children, the protection conferred by RTS,S/AS01 was found to rapidly decline, particularly in infants. <br/>Although RTS,S/AS01 was approved by the European Medicines Agency for active immunization of children aged 6 weeks to 17 months against malaria, the WHO did not recommend the inclusion of RTS,S/AS01 in the Expanded Programme of Immunisations (EPI). <br/>Instead of aiming for inclusion of the vaccine in EPI, we propose that the future development of RTS,S/AS01 could take advantage of its high transient protective efficacy. <br/>Adding the vaccine to intensive malaria elimination strategies in low-endemicity areas could be the critical factor in interrupting transmission. |
| first_indexed | 2024-03-07T02:54:40Z |
| format | Journal article |
| id | oxford-uuid:aedbf19a-1e67-4104-a26f-8c0f003f23be |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:54:40Z |
| publishDate | 2015 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:aedbf19a-1e67-4104-a26f-8c0f003f23be2022-03-27T03:45:37ZThe future of the RTS,S/AS01 malaria vaccine: an alternative development planJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aedbf19a-1e67-4104-a26f-8c0f003f23beEnglishSymplectic Elements at OxfordPublic Library of Science2015Gosling, Rvon Seidlein, LRTS,S/AS01 is the falciparum malaria vaccine candidate that is most advanced in development, globally.<br/> In a large clinical trial in sub-Saharan African children, the protection conferred by RTS,S/AS01 was found to rapidly decline, particularly in infants. <br/>Although RTS,S/AS01 was approved by the European Medicines Agency for active immunization of children aged 6 weeks to 17 months against malaria, the WHO did not recommend the inclusion of RTS,S/AS01 in the Expanded Programme of Immunisations (EPI). <br/>Instead of aiming for inclusion of the vaccine in EPI, we propose that the future development of RTS,S/AS01 could take advantage of its high transient protective efficacy. <br/>Adding the vaccine to intensive malaria elimination strategies in low-endemicity areas could be the critical factor in interrupting transmission. |
| spellingShingle | Gosling, R von Seidlein, L The future of the RTS,S/AS01 malaria vaccine: an alternative development plan |
| title | The future of the RTS,S/AS01 malaria vaccine: an alternative development plan |
| title_full | The future of the RTS,S/AS01 malaria vaccine: an alternative development plan |
| title_fullStr | The future of the RTS,S/AS01 malaria vaccine: an alternative development plan |
| title_full_unstemmed | The future of the RTS,S/AS01 malaria vaccine: an alternative development plan |
| title_short | The future of the RTS,S/AS01 malaria vaccine: an alternative development plan |
| title_sort | future of the rts s as01 malaria vaccine an alternative development plan |
| work_keys_str_mv | AT goslingr thefutureofthertssas01malariavaccineanalternativedevelopmentplan AT vonseidleinl thefutureofthertssas01malariavaccineanalternativedevelopmentplan AT goslingr futureofthertssas01malariavaccineanalternativedevelopmentplan AT vonseidleinl futureofthertssas01malariavaccineanalternativedevelopmentplan |