Genome-wide association mapping in bacteria?
Bacteria display many interesting phenotypes such as virulence, tissue specificity and host range, for which it would be useful to know the genetic basis. Association mapping involves identifying causal variants by showing that particular genotypes are statistically associated with a phenotypic trai...
| Autors principals: | , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
2006
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| _version_ | 1826291137651933184 |
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| author | Falush, D Bowden, R |
| author_facet | Falush, D Bowden, R |
| author_sort | Falush, D |
| collection | OXFORD |
| description | Bacteria display many interesting phenotypes such as virulence, tissue specificity and host range, for which it would be useful to know the genetic basis. Association mapping involves identifying causal variants by showing that particular genotypes are statistically associated with a phenotypic trait in a sample of strains taken from a natural population. With the advent of high-throughput genotyping, association mapping is becoming an increasingly powerful approach. However, until recently, association studies had not been used in bacteria because of their strong population structure, which can produce false positives and/or loss of statistical power unless elucidated and taken into account in analyses. Here, we describe how association mapping could be successfully applied to bacteria and outline the necessary sampling and genotyping strategies. |
| first_indexed | 2024-03-07T02:54:53Z |
| format | Journal article |
| id | oxford-uuid:aeece97d-8042-4ad1-8098-1e44d0e3b816 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:54:53Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:aeece97d-8042-4ad1-8098-1e44d0e3b8162022-03-27T03:46:06ZGenome-wide association mapping in bacteria?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aeece97d-8042-4ad1-8098-1e44d0e3b816EnglishSymplectic Elements at Oxford2006Falush, DBowden, RBacteria display many interesting phenotypes such as virulence, tissue specificity and host range, for which it would be useful to know the genetic basis. Association mapping involves identifying causal variants by showing that particular genotypes are statistically associated with a phenotypic trait in a sample of strains taken from a natural population. With the advent of high-throughput genotyping, association mapping is becoming an increasingly powerful approach. However, until recently, association studies had not been used in bacteria because of their strong population structure, which can produce false positives and/or loss of statistical power unless elucidated and taken into account in analyses. Here, we describe how association mapping could be successfully applied to bacteria and outline the necessary sampling and genotyping strategies. |
| spellingShingle | Falush, D Bowden, R Genome-wide association mapping in bacteria? |
| title | Genome-wide association mapping in bacteria? |
| title_full | Genome-wide association mapping in bacteria? |
| title_fullStr | Genome-wide association mapping in bacteria? |
| title_full_unstemmed | Genome-wide association mapping in bacteria? |
| title_short | Genome-wide association mapping in bacteria? |
| title_sort | genome wide association mapping in bacteria |
| work_keys_str_mv | AT falushd genomewideassociationmappinginbacteria AT bowdenr genomewideassociationmappinginbacteria |