Poor self-reported sleep is related to regional cortical thinning in aging but not memory decline – results from the Lifebrain consortium
We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2020
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| _version_ | 1811140470489743360 |
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| author | Fjell, AM Sørensen, Ø Amlien, IK Bartrés-Faz, D Brandmaier, AM Buchmann, N Demuth, I Drevon, CA Düzel, S Ebmeier, KP Ghisletta, P Idland, A-V Kietzmann, TC Kievit, RA Kühn, S Lindenberger, U Magnussen, F Macià, D Mowinckel, AM Nyberg, L Sexton, CE Solé-Padullés, C Pudas, S Roe, JM Sederevicius, D Suri, S Vidal-Piñeiro, D Wagner, G Watne, LO Westerhausen, R Zsoldos, E Walhovd, KB |
| author_facet | Fjell, AM Sørensen, Ø Amlien, IK Bartrés-Faz, D Brandmaier, AM Buchmann, N Demuth, I Drevon, CA Düzel, S Ebmeier, KP Ghisletta, P Idland, A-V Kietzmann, TC Kievit, RA Kühn, S Lindenberger, U Magnussen, F Macià, D Mowinckel, AM Nyberg, L Sexton, CE Solé-Padullés, C Pudas, S Roe, JM Sederevicius, D Suri, S Vidal-Piñeiro, D Wagner, G Watne, LO Westerhausen, R Zsoldos, E Walhovd, KB |
| author_sort | Fjell, AM |
| collection | OXFORD |
| description | We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18–92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. “PSQI # 1 Subjective sleep quality” and “PSQI #5 Sleep disturbances” were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with “PSQI #5 Sleep disturbances” emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.
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| first_indexed | 2024-03-07T02:55:14Z |
| format | Journal article |
| id | oxford-uuid:af0d3485-2676-4aef-baea-c4db316904c1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:22:30Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:af0d3485-2676-4aef-baea-c4db316904c12024-08-12T11:17:38ZPoor self-reported sleep is related to regional cortical thinning in aging but not memory decline – results from the Lifebrain consortiumJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:af0d3485-2676-4aef-baea-c4db316904c1EnglishSymplectic ElementsOxford University Press2020Fjell, AMSørensen, ØAmlien, IKBartrés-Faz, DBrandmaier, AMBuchmann, NDemuth, IDrevon, CADüzel, SEbmeier, KPGhisletta, PIdland, A-VKietzmann, TCKievit, RAKühn, SLindenberger, UMagnussen, FMacià, DMowinckel, AMNyberg, LSexton, CESolé-Padullés, CPudas, SRoe, JMSederevicius, DSuri, SVidal-Piñeiro, DWagner, GWatne, LOWesterhausen, RZsoldos, EWalhovd, KBWe examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18–92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. “PSQI # 1 Subjective sleep quality” and “PSQI #5 Sleep disturbances” were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with “PSQI #5 Sleep disturbances” emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults. |
| spellingShingle | Fjell, AM Sørensen, Ø Amlien, IK Bartrés-Faz, D Brandmaier, AM Buchmann, N Demuth, I Drevon, CA Düzel, S Ebmeier, KP Ghisletta, P Idland, A-V Kietzmann, TC Kievit, RA Kühn, S Lindenberger, U Magnussen, F Macià, D Mowinckel, AM Nyberg, L Sexton, CE Solé-Padullés, C Pudas, S Roe, JM Sederevicius, D Suri, S Vidal-Piñeiro, D Wagner, G Watne, LO Westerhausen, R Zsoldos, E Walhovd, KB Poor self-reported sleep is related to regional cortical thinning in aging but not memory decline – results from the Lifebrain consortium |
| title | Poor self-reported sleep is related to regional cortical thinning in aging but not memory decline – results from the Lifebrain consortium |
| title_full | Poor self-reported sleep is related to regional cortical thinning in aging but not memory decline – results from the Lifebrain consortium |
| title_fullStr | Poor self-reported sleep is related to regional cortical thinning in aging but not memory decline – results from the Lifebrain consortium |
| title_full_unstemmed | Poor self-reported sleep is related to regional cortical thinning in aging but not memory decline – results from the Lifebrain consortium |
| title_short | Poor self-reported sleep is related to regional cortical thinning in aging but not memory decline – results from the Lifebrain consortium |
| title_sort | poor self reported sleep is related to regional cortical thinning in aging but not memory decline results from the lifebrain consortium |
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