Endothelin-1 increases susceptibility of isolated rat hearts to ischemia/reperfusion injury by reducing coronary flow.

Endothelin-1 increases susceptibility of isolated rat hearts to ischemia/reperfusion injury by reducing coronary flow.

Endothelin-1 (ET-1) is the most potent vasoconstrictor known to date, and it was proposed that this peptide plays a major role in myocardial ischemia/reperfusion injury. ET-1 could increase myocardial susceptibility to ischemia by two mechanisms: via coronary flow reduction and/or via direct, metabo...

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Dettagli Bibliografici
Autori principali:	Groot, d, Illing, B, Horn, M, Urban, B, Haase, A, Schnackerz, K, Neubauer, S
Natura:	Journal article
Lingua:	English
Pubblicazione:	1998

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