Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries
DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined...
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Detaylı Bibliyografya
| Asıl Yazarlar: |
Matysiak, S,
Hellmuth, K,
El-Sagheer, A,
Shivalingam, A,
Ariyurek, Y,
de Jong, M,
Hollestelle, M,
Out, R,
Brown, T |
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| Materyal Türü: | Journal article
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| Dil: | English |
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| Baskı/Yayın Bilgisi: |
Royal Society of Chemistry
2017
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