Construction of microbial platform chassis for CO2 utilisation
To achieve a circular bioeconomy, carbon streams can be utilised through microbial conversion to produce value-added compounds. Although some microorganisms are naturally able to grow on these renewable carbon sources and generate desirable molecules, significant engineering is required to develop p...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2023
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| _version_ | 1826311865366478848 |
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| author | Della Valle, S Tu, W Huang, WE |
| author_facet | Della Valle, S Tu, W Huang, WE |
| author_sort | Della Valle, S |
| collection | OXFORD |
| description | To achieve a circular bioeconomy, carbon streams can be utilised through microbial conversion to produce value-added compounds. Although some microorganisms are naturally able to grow on these renewable carbon sources and generate desirable molecules, significant engineering is required to develop platform chassis exhibiting attractive performance parameters for industrial-scale processes. Here, we provide a brief overview of the core considerations in chassis engineering for autotrophic bioproduction, including carbon and energy supply, in addition to emerging standards for rewiring metabolic pathways to enhance growth and biosynthetic capabilities. We highlight examples of successful strategies, placing emphasis on recent advances in engineering autotrophic capabilities in both native autotrophs and heterotrophs. |
| first_indexed | 2024-03-07T08:17:35Z |
| format | Journal article |
| id | oxford-uuid:af2565c8-b95c-4ce6-90f6-cf06a1d0245c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:17:35Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:af2565c8-b95c-4ce6-90f6-cf06a1d0245c2024-01-11T14:54:10ZConstruction of microbial platform chassis for CO2 utilisationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:af2565c8-b95c-4ce6-90f6-cf06a1d0245cEnglishSymplectic ElementsElsevier2023Della Valle, STu, WHuang, WETo achieve a circular bioeconomy, carbon streams can be utilised through microbial conversion to produce value-added compounds. Although some microorganisms are naturally able to grow on these renewable carbon sources and generate desirable molecules, significant engineering is required to develop platform chassis exhibiting attractive performance parameters for industrial-scale processes. Here, we provide a brief overview of the core considerations in chassis engineering for autotrophic bioproduction, including carbon and energy supply, in addition to emerging standards for rewiring metabolic pathways to enhance growth and biosynthetic capabilities. We highlight examples of successful strategies, placing emphasis on recent advances in engineering autotrophic capabilities in both native autotrophs and heterotrophs. |
| spellingShingle | Della Valle, S Tu, W Huang, WE Construction of microbial platform chassis for CO2 utilisation |
| title | Construction of microbial platform chassis for CO2 utilisation |
| title_full | Construction of microbial platform chassis for CO2 utilisation |
| title_fullStr | Construction of microbial platform chassis for CO2 utilisation |
| title_full_unstemmed | Construction of microbial platform chassis for CO2 utilisation |
| title_short | Construction of microbial platform chassis for CO2 utilisation |
| title_sort | construction of microbial platform chassis for co2 utilisation |
| work_keys_str_mv | AT dellavalles constructionofmicrobialplatformchassisforco2utilisation AT tuw constructionofmicrobialplatformchassisforco2utilisation AT huangwe constructionofmicrobialplatformchassisforco2utilisation |