Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measu...

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Bibliographic Details
Main Authors: Meng, X, Navoly, G, Giannakopoulou, O, Levey, DF, Koller, D, Pathak, GA, Koen, N, Lin, K, Adams, MJ, Rentería, ME, Feng, Y, Gaziano, JM, Stein, DJ, Zar, HJ, Campbell, ML, van Heel, DA, Trivedi, B, Finer, S, McQuillin, A, Bass, N, Chundru, VK, Martin, HC, Huang, QQ, Valkovskaya, M, Chu, C-Y, Kanjira, S, Kuo, P-H, Chen, H-C, Tsai, S-J, Liu, Y-L, Kendler, KS, Peterson, RE, Cai, N, Fang, Y, Sen, S, Scott, LJ, Burmeister, M, Loos, RJF, Preuss, MH, Actkins, KV, Davis, LK, Uddin, M, Wani, AH, Wildman, DE, Aiello, AE, Ursano, RJ, Kessler, RC, Kanai, M, Okada, Y, Sakaue, S, Millwood, IY, Chen, Z, Walters, RG
Other Authors: PGC-MDD Working Group
Format: Journal article
Language:English
Published: Springer Nature 2024

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