High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients.

High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients.

The mechanisms behind destruction of the adrenal glands in autoimmune Addison's disease remain unclear. Autoantibodies against steroid 21-hydroxylase, an intracellular key enzyme of the adrenal cortex, are found in >90% of patients, but these autoantibodies are not thought to mediate the...

Full description

Bibliographic Details
Main Authors: Dawoodji, A, Chen, J, Shepherd, D, Dalin, F, Tarlton, A, Alimohammadi, M, Penna-Martinez, M, Meyer, G, Mitchell, A, Gan, E, Bratland, E, Bensing, S, Husebye, E, Pearce, S, Badenhoop, K, Kämpe, O, Cerundolo, V
Format: Journal article
Language:English
Published: American Association of Immunologists 2014

Similar Items

Similar Items