Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer.

Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer.

We evaluated the safety and immunogencity of a novel vaccine directed against autologous TNFalpha in a Phase I fixed dose escalation trial. The vaccine consisted of two recombinant TNFalpha proteins, with specific peptides replaced by foreign immunodominant T cell epitopes from tetanus toxoid. The m...

Full description

Bibliographic Details
Main Authors: Waterston, A, Gumbrell, L, Bratt, T, Waller, S, Gustav-Aspland, J, L'hermenier, C, Bellenger, K, Campbell, M, Powles, T, Highley, M, Bower, M, Mouritsen, S, Feldmann, M, Coombes, R
Format: Journal article
Language:English
Published: 2005

Similar Items

Similar Items