The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma.

The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma.

Clear cell renal cell cancer (CC-RCC) is a highly chemoresistant tumor characterized by frequent inactivation of the von Hippel-Lindau (VHL) gene. The prognosis is reportedly worse in patients whose tumors express immunoreactive type I insulin-like growth factor receptor (IGF1R), a key mediator of t...

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Bibliographic Details
Main Authors: Yuen, J, Cockman, M, Sullivan, M, Protheroe, A, Turner, G, Roberts, I, Pugh, C, Werner, H, Macaulay, V
Format: Journal article
Language:English
Published: 2007

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