A pro-survival DNA damage-induced cytoplasmic interferon response is mediated by end-resection factors, and is limited by Trex1

Radiotherapy and chemotherapy are effective treatment methods for many types of cancer, but resistance is common. Recent findings indicate that anti-viral type I interferon (IFN) signaling is induced by these treatments. However, the underlying mechanisms still need to be elucidated. Expression of a...

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Bibliographic Details
Main Authors: Erdal, E, Haider, S, Rehwinkel, J, Harris, A, Mchugh, P
Format: Journal article
Published: Cold Spring Harbor Laboratory Press 2017