Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition.
Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2007
|
| _version_ | 1826291280565501952 |
|---|---|
| author | Jenab, M Riboli, E Cleveland, R Norat, T Rinaldi, S Nieters, A Biessy, C Tjønneland, A Olsen, A Overvad, K Grønbaek, H Clavel-Chapelon, F Boutron-Ruault, M Linseisen, J Boeing, H Pischon, T Trichopoulos, D Oikonomou, E Trichopoulou, A Panico, S Vineis, P Berrino, F Tumino, R Masala, G Peters, P |
| author_facet | Jenab, M Riboli, E Cleveland, R Norat, T Rinaldi, S Nieters, A Biessy, C Tjønneland, A Olsen, A Overvad, K Grønbaek, H Clavel-Chapelon, F Boutron-Ruault, M Linseisen, J Boeing, H Pischon, T Trichopoulos, D Oikonomou, E Trichopoulou, A Panico, S Vineis, P Berrino, F Tumino, R Masala, G Peters, P |
| author_sort | Jenab, M |
| collection | OXFORD |
| description | Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increasing levels of serum C-peptide, a biomarker of pancreatic insulin secretion, and IGF binding proteins (IGFBP) -1 and -2 with colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 Western European countries. A total of 1,078 colorectal cancer cases were matched (age, date of blood donation, fasting status, gender, study center) to an equal number of control subjects. Relative cancer risks were estimated using conditional logistic regression models. Serum C-peptide concentration was positively associated with an increased colorectal cancer risk for the highest versus the lowest quintile (OR=1.56, 95% CI=1.16-2.09, p(trend)<0.01), which was slightly attenuated after adjustment for BMI and physical activity (OR=1.37, 95% CI=1.00-1.88, p(trend)=0.10). When stratified by anatomical site, the cancer risk was stronger in the colon (OR=1.67, 95% CI=1.14-2.46, p(trend)<0.01) than in the rectum (OR=1.42, 95% CI=0.90-2.25, p(trend)=0.35). The cancer risk estimates were not heterogeneous by gender or fasting status. No clear colorectal cancer risk associations were observed for IGFBP-1 or -2. This large prospective study confirms that hyperinsulinemia, as determined by C-peptide levels, is associated with an increased colorectal cancer risk. |
| first_indexed | 2024-03-07T02:57:04Z |
| format | Journal article |
| id | oxford-uuid:afae3d2d-5c5c-4ff4-a80d-9c99fe4fa9f3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:57:04Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:afae3d2d-5c5c-4ff4-a80d-9c99fe4fa9f32022-03-27T03:51:11ZSerum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:afae3d2d-5c5c-4ff4-a80d-9c99fe4fa9f3EnglishSymplectic Elements at Oxford2007Jenab, MRiboli, ECleveland, RNorat, TRinaldi, SNieters, ABiessy, CTjønneland, AOlsen, AOvervad, KGrønbaek, HClavel-Chapelon, FBoutron-Ruault, MLinseisen, JBoeing, HPischon, TTrichopoulos, DOikonomou, ETrichopoulou, APanico, SVineis, PBerrino, FTumino, RMasala, GPeters, PWestern style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increasing levels of serum C-peptide, a biomarker of pancreatic insulin secretion, and IGF binding proteins (IGFBP) -1 and -2 with colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 Western European countries. A total of 1,078 colorectal cancer cases were matched (age, date of blood donation, fasting status, gender, study center) to an equal number of control subjects. Relative cancer risks were estimated using conditional logistic regression models. Serum C-peptide concentration was positively associated with an increased colorectal cancer risk for the highest versus the lowest quintile (OR=1.56, 95% CI=1.16-2.09, p(trend)<0.01), which was slightly attenuated after adjustment for BMI and physical activity (OR=1.37, 95% CI=1.00-1.88, p(trend)=0.10). When stratified by anatomical site, the cancer risk was stronger in the colon (OR=1.67, 95% CI=1.14-2.46, p(trend)<0.01) than in the rectum (OR=1.42, 95% CI=0.90-2.25, p(trend)=0.35). The cancer risk estimates were not heterogeneous by gender or fasting status. No clear colorectal cancer risk associations were observed for IGFBP-1 or -2. This large prospective study confirms that hyperinsulinemia, as determined by C-peptide levels, is associated with an increased colorectal cancer risk. |
| spellingShingle | Jenab, M Riboli, E Cleveland, R Norat, T Rinaldi, S Nieters, A Biessy, C Tjønneland, A Olsen, A Overvad, K Grønbaek, H Clavel-Chapelon, F Boutron-Ruault, M Linseisen, J Boeing, H Pischon, T Trichopoulos, D Oikonomou, E Trichopoulou, A Panico, S Vineis, P Berrino, F Tumino, R Masala, G Peters, P Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. |
| title | Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. |
| title_full | Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. |
| title_fullStr | Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. |
| title_full_unstemmed | Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. |
| title_short | Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. |
| title_sort | serum c peptide igfbp 1 and igfbp 2 and risk of colon and rectal cancers in the european prospective investigation into cancer and nutrition |
| work_keys_str_mv | AT jenabm serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT ribolie serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT clevelandr serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT noratt serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT rinaldis serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT nietersa serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT biessyc serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT tjønnelanda serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT olsena serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT overvadk serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT grønbaekh serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT clavelchapelonf serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT boutronruaultm serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT linseisenj serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT boeingh serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT pischont serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT trichopoulosd serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT oikonomoue serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT trichopouloua serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT panicos serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT vineisp serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT berrinof serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT tuminor serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT masalag serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition AT petersp serumcpeptideigfbp1andigfbp2andriskofcolonandrectalcancersintheeuropeanprospectiveinvestigationintocancerandnutrition |