The 5-HTTLPR polymorphism, early and recent life stress, and cognitive endophenotypes of depression
Studies associating interactions of 5-HTTLPR and life adversities with depression have yielded equivocal results. Studying endophenotypes may constitute a more powerful approach. In the current study, it was assessed whether interactions of 5-HTTLPR with childhood emotional abuse (CEA) and recent ne...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Routledge
2014
|
| _version_ | 1826291290325647360 |
|---|---|
| author | Kruijt, J Putman, P Van der Does, W |
| author_facet | Kruijt, J Putman, P Van der Does, W |
| author_sort | Kruijt, J |
| collection | OXFORD |
| description | Studies associating interactions of 5-HTTLPR and life adversities with depression have yielded equivocal results. Studying endophenotypes may constitute a more powerful approach. In the current study, it was assessed whether interactions of 5-HTTLPR with childhood emotional abuse (CEA) and recent negative life events (RNLE) affect possible cognitive endophenotypes of depression, namely, attention-allocation bias and the ability to recognise others' mind states in 215 young adults of North-West European descent. The ability to classify others' negative mind states was found to be increased with increasing RNLE in carriers of low-expressing Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) alleles. Carriers of two low-expressing alleles also preferentially oriented attention towards negative information. Gene-environment interactions were not observed for attention allocation bias. No effects involving CEA were observed. These results suggest that low-expressing 5-HTTLPR alleles may confer increased risk for depression through enhanced recognition of negative facial expressions following RNLE. |
| first_indexed | 2024-03-07T02:57:13Z |
| format | Journal article |
| id | oxford-uuid:afba53d0-0ffd-4927-adc8-55db9615b455 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:57:13Z |
| publishDate | 2014 |
| publisher | Routledge |
| record_format | dspace |
| spelling | oxford-uuid:afba53d0-0ffd-4927-adc8-55db9615b4552022-03-27T03:51:22ZThe 5-HTTLPR polymorphism, early and recent life stress, and cognitive endophenotypes of depressionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:afba53d0-0ffd-4927-adc8-55db9615b455EnglishSymplectic Elements at OxfordRoutledge2014Kruijt, JPutman, PVan der Does, WStudies associating interactions of 5-HTTLPR and life adversities with depression have yielded equivocal results. Studying endophenotypes may constitute a more powerful approach. In the current study, it was assessed whether interactions of 5-HTTLPR with childhood emotional abuse (CEA) and recent negative life events (RNLE) affect possible cognitive endophenotypes of depression, namely, attention-allocation bias and the ability to recognise others' mind states in 215 young adults of North-West European descent. The ability to classify others' negative mind states was found to be increased with increasing RNLE in carriers of low-expressing Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) alleles. Carriers of two low-expressing alleles also preferentially oriented attention towards negative information. Gene-environment interactions were not observed for attention allocation bias. No effects involving CEA were observed. These results suggest that low-expressing 5-HTTLPR alleles may confer increased risk for depression through enhanced recognition of negative facial expressions following RNLE. |
| spellingShingle | Kruijt, J Putman, P Van der Does, W The 5-HTTLPR polymorphism, early and recent life stress, and cognitive endophenotypes of depression |
| title | The 5-HTTLPR polymorphism, early and recent life stress, and cognitive endophenotypes of depression |
| title_full | The 5-HTTLPR polymorphism, early and recent life stress, and cognitive endophenotypes of depression |
| title_fullStr | The 5-HTTLPR polymorphism, early and recent life stress, and cognitive endophenotypes of depression |
| title_full_unstemmed | The 5-HTTLPR polymorphism, early and recent life stress, and cognitive endophenotypes of depression |
| title_short | The 5-HTTLPR polymorphism, early and recent life stress, and cognitive endophenotypes of depression |
| title_sort | 5 httlpr polymorphism early and recent life stress and cognitive endophenotypes of depression |
| work_keys_str_mv | AT kruijtj the5httlprpolymorphismearlyandrecentlifestressandcognitiveendophenotypesofdepression AT putmanp the5httlprpolymorphismearlyandrecentlifestressandcognitiveendophenotypesofdepression AT vanderdoesw the5httlprpolymorphismearlyandrecentlifestressandcognitiveendophenotypesofdepression AT kruijtj 5httlprpolymorphismearlyandrecentlifestressandcognitiveendophenotypesofdepression AT putmanp 5httlprpolymorphismearlyandrecentlifestressandcognitiveendophenotypesofdepression AT vanderdoesw 5httlprpolymorphismearlyandrecentlifestressandcognitiveendophenotypesofdepression |