The pol II CTD: new twists in the tail
The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises conserved heptad repeats, and post-translational modification of the CTD regulates transcription and cotranscriptional RNA processing. Recently, the spatial patterns of modification of the CTD repeats have been inv...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Nature Publishing Group
2016
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| _version_ | 1797088935630864384 |
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| author | Zaborowska, J Egloff, S Murphy, S |
| author_facet | Zaborowska, J Egloff, S Murphy, S |
| author_sort | Zaborowska, J |
| collection | OXFORD |
| description | The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises conserved heptad repeats, and post-translational modification of the CTD regulates transcription and cotranscriptional RNA processing. Recently, the spatial patterns of modification of the CTD repeats have been investigated, and new functions of CTD modification have been revealed. In addition, there are new insights into the roles of the enzymes that decorate the CTD. We review these new findings and reassess the role of the pol II CTD in the regulation of gene expression. |
| first_indexed | 2024-03-07T02:57:14Z |
| format | Journal article |
| id | oxford-uuid:afbbcbec-e5f6-4653-b6e1-2b24299cff54 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:57:14Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:afbbcbec-e5f6-4653-b6e1-2b24299cff542022-03-27T03:51:31ZThe pol II CTD: new twists in the tailJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:afbbcbec-e5f6-4653-b6e1-2b24299cff54EnglishSymplectic Elements at OxfordNature Publishing Group2016Zaborowska, JEgloff, SMurphy, SThe C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises conserved heptad repeats, and post-translational modification of the CTD regulates transcription and cotranscriptional RNA processing. Recently, the spatial patterns of modification of the CTD repeats have been investigated, and new functions of CTD modification have been revealed. In addition, there are new insights into the roles of the enzymes that decorate the CTD. We review these new findings and reassess the role of the pol II CTD in the regulation of gene expression. |
| spellingShingle | Zaborowska, J Egloff, S Murphy, S The pol II CTD: new twists in the tail |
| title | The pol II CTD: new twists in the tail |
| title_full | The pol II CTD: new twists in the tail |
| title_fullStr | The pol II CTD: new twists in the tail |
| title_full_unstemmed | The pol II CTD: new twists in the tail |
| title_short | The pol II CTD: new twists in the tail |
| title_sort | pol ii ctd new twists in the tail |
| work_keys_str_mv | AT zaborowskaj thepoliictdnewtwistsinthetail AT egloffs thepoliictdnewtwistsinthetail AT murphys thepoliictdnewtwistsinthetail AT zaborowskaj poliictdnewtwistsinthetail AT egloffs poliictdnewtwistsinthetail AT murphys poliictdnewtwistsinthetail |