Binding of tritiated yohimbine to platelets in women with maternity blues.
Platelet alpha 2-adrenoceptor binding was measured in 108 women in the 36th week of pregnancy, at ten and twenty days and at three and six months post-partum. An age matched non-pregnant control group of women (N = 25) was also studied. The number (Bmax) of alpha 2-adrenoceptors was elevated antepar...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1988
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| _version_ | 1797088948635303936 |
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| author | Best, N Wiley, M Stump, K Elliott, J Cowen, P |
| author_facet | Best, N Wiley, M Stump, K Elliott, J Cowen, P |
| author_sort | Best, N |
| collection | OXFORD |
| description | Platelet alpha 2-adrenoceptor binding was measured in 108 women in the 36th week of pregnancy, at ten and twenty days and at three and six months post-partum. An age matched non-pregnant control group of women (N = 25) was also studied. The number (Bmax) of alpha 2-adrenoceptors was elevated antepartum but fell to control values on the tenth post-partum day. At three and six months post-partum, however, alpha 2-adrenoceptor Bmax was again increased. Women who developed maternity blues (N = 59) had significantly more platelet alpha 2-adrenoceptors than those who did not (N = 49) at both ten and twenty days post-partum. In addition their alpha 2-adrenoceptor Bmax was greater than controls at all time points measured except the tenth post-partum day. In contrast, the alpha 2-adrenoceptor Bmax of women without the blues did not differ from controls at any stage. It is suggested that women who develop maternity blues may have a relatively enduring abnormality in alpha 2-adrenoceptor sensitivity which is associated with psychological symptoms when concentrations of circulating sex-steroids suddenly change. |
| first_indexed | 2024-03-07T02:57:25Z |
| format | Journal article |
| id | oxford-uuid:afcb55fd-a695-4b09-a68e-d690ad5b654e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:57:25Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:afcb55fd-a695-4b09-a68e-d690ad5b654e2022-03-27T03:51:52ZBinding of tritiated yohimbine to platelets in women with maternity blues.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:afcb55fd-a695-4b09-a68e-d690ad5b654eEnglishSymplectic Elements at Oxford1988Best, NWiley, MStump, KElliott, JCowen, PPlatelet alpha 2-adrenoceptor binding was measured in 108 women in the 36th week of pregnancy, at ten and twenty days and at three and six months post-partum. An age matched non-pregnant control group of women (N = 25) was also studied. The number (Bmax) of alpha 2-adrenoceptors was elevated antepartum but fell to control values on the tenth post-partum day. At three and six months post-partum, however, alpha 2-adrenoceptor Bmax was again increased. Women who developed maternity blues (N = 59) had significantly more platelet alpha 2-adrenoceptors than those who did not (N = 49) at both ten and twenty days post-partum. In addition their alpha 2-adrenoceptor Bmax was greater than controls at all time points measured except the tenth post-partum day. In contrast, the alpha 2-adrenoceptor Bmax of women without the blues did not differ from controls at any stage. It is suggested that women who develop maternity blues may have a relatively enduring abnormality in alpha 2-adrenoceptor sensitivity which is associated with psychological symptoms when concentrations of circulating sex-steroids suddenly change. |
| spellingShingle | Best, N Wiley, M Stump, K Elliott, J Cowen, P Binding of tritiated yohimbine to platelets in women with maternity blues. |
| title | Binding of tritiated yohimbine to platelets in women with maternity blues. |
| title_full | Binding of tritiated yohimbine to platelets in women with maternity blues. |
| title_fullStr | Binding of tritiated yohimbine to platelets in women with maternity blues. |
| title_full_unstemmed | Binding of tritiated yohimbine to platelets in women with maternity blues. |
| title_short | Binding of tritiated yohimbine to platelets in women with maternity blues. |
| title_sort | binding of tritiated yohimbine to platelets in women with maternity blues |
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