The effects of paroxetine and nefazodone on sleep: a placebo controlled trial.
We studied the effect of acute (1 day) and subacute (16 days) administration of the new antidepressant, nefazodone (400 mg daily), and the selective serotonin re-uptake inhibitor (SSRI), paroxetine (30 mg daily), on the sleep polysomnogram of 37 healthy volunteers using a random allocation, double-b...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1996
|
| _version_ | 1826291320717574144 |
|---|---|
| author | Sharpley, A Williamson, D Attenburrow, M Pearson, G Sargent, P Cowen, P |
| author_facet | Sharpley, A Williamson, D Attenburrow, M Pearson, G Sargent, P Cowen, P |
| author_sort | Sharpley, A |
| collection | OXFORD |
| description | We studied the effect of acute (1 day) and subacute (16 days) administration of the new antidepressant, nefazodone (400 mg daily), and the selective serotonin re-uptake inhibitor (SSRI), paroxetine (30 mg daily), on the sleep polysomnogram of 37 healthy volunteers using a random allocation, double-blind, placebo-controlled design. Compared to placebo, paroxetine lowered rapid eye movement (REM) sleep and increased REM latency. In addition, paroxetine increased awakenings and reduced Actual Sleep Time and Sleep Efficiency. In contrast, nefazodone did not alter REM sleep and had little effect on measures of sleep continuity. We conclude that in contrast to typical SSRIs, nefazodone administration has little effect on sleep architecture in healthy volunteers. |
| first_indexed | 2024-03-07T02:57:40Z |
| format | Journal article |
| id | oxford-uuid:afe10165-8ea8-4bb5-b42d-bbf7bf6b2a9f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:57:40Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:afe10165-8ea8-4bb5-b42d-bbf7bf6b2a9f2022-03-27T03:52:24ZThe effects of paroxetine and nefazodone on sleep: a placebo controlled trial.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:afe10165-8ea8-4bb5-b42d-bbf7bf6b2a9fEnglishSymplectic Elements at Oxford1996Sharpley, AWilliamson, DAttenburrow, MPearson, GSargent, PCowen, PWe studied the effect of acute (1 day) and subacute (16 days) administration of the new antidepressant, nefazodone (400 mg daily), and the selective serotonin re-uptake inhibitor (SSRI), paroxetine (30 mg daily), on the sleep polysomnogram of 37 healthy volunteers using a random allocation, double-blind, placebo-controlled design. Compared to placebo, paroxetine lowered rapid eye movement (REM) sleep and increased REM latency. In addition, paroxetine increased awakenings and reduced Actual Sleep Time and Sleep Efficiency. In contrast, nefazodone did not alter REM sleep and had little effect on measures of sleep continuity. We conclude that in contrast to typical SSRIs, nefazodone administration has little effect on sleep architecture in healthy volunteers. |
| spellingShingle | Sharpley, A Williamson, D Attenburrow, M Pearson, G Sargent, P Cowen, P The effects of paroxetine and nefazodone on sleep: a placebo controlled trial. |
| title | The effects of paroxetine and nefazodone on sleep: a placebo controlled trial. |
| title_full | The effects of paroxetine and nefazodone on sleep: a placebo controlled trial. |
| title_fullStr | The effects of paroxetine and nefazodone on sleep: a placebo controlled trial. |
| title_full_unstemmed | The effects of paroxetine and nefazodone on sleep: a placebo controlled trial. |
| title_short | The effects of paroxetine and nefazodone on sleep: a placebo controlled trial. |
| title_sort | effects of paroxetine and nefazodone on sleep a placebo controlled trial |
| work_keys_str_mv | AT sharpleya theeffectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT williamsond theeffectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT attenburrowm theeffectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT pearsong theeffectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT sargentp theeffectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT cowenp theeffectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT sharpleya effectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT williamsond effectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT attenburrowm effectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT pearsong effectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT sargentp effectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial AT cowenp effectsofparoxetineandnefazodoneonsleepaplacebocontrolledtrial |