Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
Effects of extracellularly applied ATP (added as disodium salt) on stimulus-secretion coupling were investigated in clonal insulin-producing RINm5F cells. Cytoplasmic free Ca2+ concentration [( Ca2+]i), electrical activity, membrane potential, formation of InsP3 and insulin release were measured. Ad...
Үндсэн зохиолчид: | Arkhammar, P, Hallberg, A, Kindmark, H, Nilsson, T, Rorsman, P, Berggren, P |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
1990
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