Early development of synchrony in cortical activations in the human
Early intermittent cortical activity is thought to play a crucial role in the growth of neuronal network development, and large scale brain networks are known to provide the basis for higher brain functions. Yet, the early development of the large scale synchrony in cortical activations is unknown....
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
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Elsevier
2016
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| _version_ | 1826291345925341184 |
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| author | De Vos, M Ninah, K Dereymaeker, A Räsänen, O Jansen, K Vervisch, J Matic, V Naulaers, G Van Huffel, S Vanhatalo, S |
| author_facet | De Vos, M Ninah, K Dereymaeker, A Räsänen, O Jansen, K Vervisch, J Matic, V Naulaers, G Van Huffel, S Vanhatalo, S |
| author_sort | De Vos, M |
| collection | OXFORD |
| description | Early intermittent cortical activity is thought to play a crucial role in the growth of neuronal network development, and large scale brain networks are known to provide the basis for higher brain functions. Yet, the early development of the large scale synchrony in cortical activations is unknown. Here, we tested the hypothesis that the early intermittent cortical activations seen in the human scalp EEG show a clear developmental course during the last trimester of pregnancy, the period of intensive growth of cortico-cortical connections. We recorded scalp EEG from altogether 22 premature infants at post-menstrual age between 30 to 44 weeks, and the early cortical synchrony was quantified using recently introduced activation synchrony index (ASI). The developmental correlations of ASI were computed for individual EEG signals as well as anatomically and mathematically defined spatial subgroups. We report two main findings. First, we observed a robust and statistically significant increase in ASI in all cortical areas. Second, there were significant spatial gradients in the synchrony in frontooccipital and left-to-right directions. These findings provide evidence that early cortical activity is increasingly synchronized across the neocortex. The ASI-based metrics introduced in our work allow direct translational comparison to in vivo animal models, as well as hold promise for implementation as a functional developmental biomarker in future research on human neonates. |
| first_indexed | 2024-03-07T02:58:01Z |
| format | Journal article |
| id | oxford-uuid:affb3ac2-c2bf-47fc-8530-44b690cdda2c |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:58:01Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:affb3ac2-c2bf-47fc-8530-44b690cdda2c2022-03-27T03:53:13ZEarly development of synchrony in cortical activations in the humanJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:affb3ac2-c2bf-47fc-8530-44b690cdda2cSymplectic Elements at OxfordElsevier2016De Vos, MNinah, KDereymaeker, ARäsänen, OJansen, KVervisch, JMatic, VNaulaers, GVan Huffel, SVanhatalo, SEarly intermittent cortical activity is thought to play a crucial role in the growth of neuronal network development, and large scale brain networks are known to provide the basis for higher brain functions. Yet, the early development of the large scale synchrony in cortical activations is unknown. Here, we tested the hypothesis that the early intermittent cortical activations seen in the human scalp EEG show a clear developmental course during the last trimester of pregnancy, the period of intensive growth of cortico-cortical connections. We recorded scalp EEG from altogether 22 premature infants at post-menstrual age between 30 to 44 weeks, and the early cortical synchrony was quantified using recently introduced activation synchrony index (ASI). The developmental correlations of ASI were computed for individual EEG signals as well as anatomically and mathematically defined spatial subgroups. We report two main findings. First, we observed a robust and statistically significant increase in ASI in all cortical areas. Second, there were significant spatial gradients in the synchrony in frontooccipital and left-to-right directions. These findings provide evidence that early cortical activity is increasingly synchronized across the neocortex. The ASI-based metrics introduced in our work allow direct translational comparison to in vivo animal models, as well as hold promise for implementation as a functional developmental biomarker in future research on human neonates. |
| spellingShingle | De Vos, M Ninah, K Dereymaeker, A Räsänen, O Jansen, K Vervisch, J Matic, V Naulaers, G Van Huffel, S Vanhatalo, S Early development of synchrony in cortical activations in the human |
| title | Early development of synchrony in cortical activations in the human |
| title_full | Early development of synchrony in cortical activations in the human |
| title_fullStr | Early development of synchrony in cortical activations in the human |
| title_full_unstemmed | Early development of synchrony in cortical activations in the human |
| title_short | Early development of synchrony in cortical activations in the human |
| title_sort | early development of synchrony in cortical activations in the human |
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