Finding the molecular basis of quantitative traits: successes and pitfalls.
Understanding the molecular basis of quantitative genetic variation is a principal goal for biomedicine. Although the complex genetic architecture of quantitative traits has so far largely frustrated attempts to identify genes in humans by standard linkage methodologies, quantitative trait loci (QTL...
| मुख्य लेखकों: | , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2001
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| _version_ | 1826291388452438016 |
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| author | Flint, J Mott, R |
| author_facet | Flint, J Mott, R |
| author_sort | Flint, J |
| collection | OXFORD |
| description | Understanding the molecular basis of quantitative genetic variation is a principal goal for biomedicine. Although the complex genetic architecture of quantitative traits has so far largely frustrated attempts to identify genes in humans by standard linkage methodologies, quantitative trait loci (QTL) have been mapped in plants, insects and rodents. However, identifying the molecular bases of QTL remains a challenge. Here, we discuss why this is and how new experimental strategies and analytical techniques, combined with the fruits of the genome projects, are beginning to identify candidate genes for QTL studies in several model organisms. |
| first_indexed | 2024-03-07T02:58:39Z |
| format | Journal article |
| id | oxford-uuid:b02e7d21-b91a-4d1c-b879-d20cf0ec6093 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:58:39Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:b02e7d21-b91a-4d1c-b879-d20cf0ec60932022-03-27T03:54:36ZFinding the molecular basis of quantitative traits: successes and pitfalls.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b02e7d21-b91a-4d1c-b879-d20cf0ec6093EnglishSymplectic Elements at Oxford2001Flint, JMott, RUnderstanding the molecular basis of quantitative genetic variation is a principal goal for biomedicine. Although the complex genetic architecture of quantitative traits has so far largely frustrated attempts to identify genes in humans by standard linkage methodologies, quantitative trait loci (QTL) have been mapped in plants, insects and rodents. However, identifying the molecular bases of QTL remains a challenge. Here, we discuss why this is and how new experimental strategies and analytical techniques, combined with the fruits of the genome projects, are beginning to identify candidate genes for QTL studies in several model organisms. |
| spellingShingle | Flint, J Mott, R Finding the molecular basis of quantitative traits: successes and pitfalls. |
| title | Finding the molecular basis of quantitative traits: successes and pitfalls. |
| title_full | Finding the molecular basis of quantitative traits: successes and pitfalls. |
| title_fullStr | Finding the molecular basis of quantitative traits: successes and pitfalls. |
| title_full_unstemmed | Finding the molecular basis of quantitative traits: successes and pitfalls. |
| title_short | Finding the molecular basis of quantitative traits: successes and pitfalls. |
| title_sort | finding the molecular basis of quantitative traits successes and pitfalls |
| work_keys_str_mv | AT flintj findingthemolecularbasisofquantitativetraitssuccessesandpitfalls AT mottr findingthemolecularbasisofquantitativetraitssuccessesandpitfalls |