PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.

Bromo and extra terminal (BET) proteins (BRD2, BRD3, BRD4, and BRDT) are transcriptional regulators required for efficient expression of several growth promoting and antiapoptotic genes as well as for cell-cycle progression. BET proteins are recruited on transcriptionally active chromatin via their...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Picaud, S, Da Costa, D, Thanasopoulou, A, Filippakopoulos, P, Fish, P, Philpott, M, Fedorov, O, Brennan, P, Bunnage, M, Owen, DR, Bradner, J, Taniere, P, O'Sullivan, B, Müller, S, Schwaller, J, Stankovic, T, Knapp, S
Format: Journal article
Sprache:English
Veröffentlicht: 2013

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