Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.

Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.

Questions exist concerning the effects of acute versus chronic hypoxic conditions on DNA replication and genomic stability that may influence tumorigenesis. Severe hypoxia causes replication arrest independent of S-phase checkpoint, DNA damage response, or transformation status. Arrests occur during...

Full description

Bibliographic Details
Main Authors:	Pires, I, Bencokova, Z, Milani, M, Folkes, L, Li, J, Stratford, MR, Harris, A, Hammond, E
Format:	Journal article
Language:	English
Published:	2010

Similar Items

Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1.
by: Pires, I, et al.
Published: (2010)

Hypoxia and the DNA Damage Response
by: Pires, I, et al.
Published: (2010)

Antimicrobial-Induced DNA Damage and Genomic Instability in Microbial Pathogens
by: Shapiro, Rebecca
Published: (2015)

DNA damage remodels the MITF interactome to increase melanoma genomic instability
by: Binet, R, et al.
Published: (2024)

Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review
by: Bolland, H, et al.
Published: (2021)

Regulation of autophagy by ATF4 in response to severe hypoxia.
by: Rzymski, T, et al.
Published: (2010)

Oxygen sensing and the DNA-damage response.
by: Hammond, E, et al.
Published: (2007)

Links between the unfolded protein response and the DNA damage response in hypoxia
by: Ma, TS
Published: (2022)

DNA repair and genomic instability in yeast aging
by: Park, Peter Unnam, 1971-
Published: (2005)

Mechanistic studies of DNA repair and genome instability
by: Nathan, WJ
Published: (2021)

Targeting tumour hypoxia in breast cancer.
by: Milani, M, et al.
Published: (2008)

Cell stress response and hypoxia in breast cancer
by: Milani, M, et al.
Published: (2011)

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.
by: Coutts, A, et al.
Published: (2011)

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α
by: Coutts, A, et al.
Published: (2011)

Modification of DNA damage mechanisms by nitric oxide during ionizing radiation.
by: Folkes, L, et al.
Published: (2013)

ATM activation and signaling under hypoxic conditions.
by: Bencokova, Z, et al.
Published: (2009)

Biological consequences of radiation-induced DNA damage: relevance to radiotherapy.
by: Lomax, M, et al.
Published: (2013)

Biological consequences of radiation-induced DNA damage: Relevance to radiotherapy
by: Lomax, M, et al.
Published: (2013)

DNA damage induced by nitric oxide during ionizing radiation is enhanced at replication.
by: Folkes, L, et al.
Published: (2013)

DNA damage induced by nitric oxide during ionizing radiation is enhanced at replication
by: Folkes, L, et al.
Published: (2013)

Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability
by: You, Delin, et al.
Published: (2018)

Web-server for discovering DNA motifs associated with genome instability
by: Lee, Yew Ti.
Published: (2012)

Quantitative determination of the anticancer prodrug combretastatin A1 phosphate (OXi4503, CA1P), the active CA1 and its glucuronide metabolites in human urine and of CA1 in plasma by HPLC with mass spectrometric detection.
by: Stratford, MR, et al.
Published: (2012)

A validated HPLC method with fluorescence detection for the glucuronides of Combretastatin A1 in human plasma, and studies on their cis-trans isomerisation.
by: Stratford, MR, et al.
Published: (2012)

Validation of a method for the determination of the anticancer agent Combretastatin A1 phosphate (CA1P, OXi4503) in human plasma by HPLC with post-column photolysis and fluorescence detection.
by: Stratford, MR, et al.
Published: (2011)

Targeting hypoxic cells through the DNA damage response.
by: Olcina, M, et al.
Published: (2010)

Iron, hypoxia and chronic disease
by: Santer, P
Published: (2018)

Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.
by: Hammond, D, et al.
Published: (2013)

The role of necrosis, acute hypoxia and chronic hypoxia in 18F-MISO PET image contrast: a computational modelling study
by: Warren, D, et al.
Published: (2016)

RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?
by: Scrace, S, et al.
Published: (2012)

Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A
by: Hammond, D, et al.
Published: (2013)

Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs
by: O'Connor, L, et al.
Published: (2016)

The role of Wee1 in the hypoxia-induced DNA damage response and its potential as a therapeutic target
by: O'Brien, EM
Published: (2012)

Tonsillectomy versus non-surgical treatment for chronic / recurrent acute tonsillitis.
by: Burton, M, et al.
Published: (2000)

Targeting ATR in DNA damage response and cancer therapeutics.
by: Fokas, E, et al.
Published: (2014)

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia.
by: Rzymski, T, et al.
Published: (2009)

Hypoxia response elements.
by: O'Rourke, J, et al.
Published: (1997)

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.
by: Clifford, R, et al.
Published: (2014)

Targeting ATR in DNA damage response and cancer therapeutics
by: Fokas, E, et al.
Published: (2014)

NOCTURNAL HYPOXIA IN CHRONIC AIRWAYS OBSTRUCTION
by: Stradling, J, et al.
Published: (1981)